Experimental investigation of heat transfer and flow resistance performance on heat exchanger with lozenge fin tubes supported by helical baffles was carried out. Under the experimental conditions，curves of relation between heat transfer film coefficient and flow velocity，relation between flow resistance coefficient and velocity were obtained，which provides references for industrial application of this type of heat exchanger. Experimental results indicated that within the range of diesel oil flow velocity 0.22—0.85 m·s-1，heat transfer film coefficient in shell side of heat exchanger with lozenge fin tubes supported by helical baffles was 512—1378 W·m-2·K-1，which was 54%—108% higher than that of heat exchanger with smooth tubes supported by helical baffles，while flow resistance coefficient was lower by 5%—30%，which showed that heat exchanger with lozenge fin tubes supported by helical baffles had favorable heat transfer and flow resistance performance.