The naturally evolved properties of enzyme catalysis in terms of chemo-

regio-

and stereo-selectivity make enzymes ideal catalysts for green synthesis of chemicals. However and unfortunately

low activity and poor stability frequently exclude enzymatic catalysis for industrial applications. The development of nanotechnology offers new opportunities to create highly efficient enzyme catalysts. The development of a facile

efficient and economical synthesis method and an easy way to operate and recycle the catalysts are the major challenges in this field. This review summarizes the recent advances in nanostructured enzyme catalysts

with the emphasis on the preparation of enzyme-inorganic hybrid nanocatalysts

enzyme metal-organic framework hybrid nanocatalysts

and the preparation of temperature-

or magnetic-responsive nanostructured enzyme catalysts. The potential applications of these nanostructured enzyme catalysts for enzymatic synthesis of pharmaceutical compounds are also discussed.