Nanoparticles based on poly(2-amino-1

3-propanediol carbonic ester-co-lactide)-g-PEG(P(LA-co-CA)-mPEG) were prepared by using the emulsion solvent diffusion method. The copolymer of P (LA-co-CA) was prepared by using ring-opening polymerization with diethylzinc (ZnEt2) as initiator

and then benzyl oxygen group was taken off to obtain P (LA-co-CA). With the anticancer drug

docetaxel (DTX)

as a model drug

the morphology of nanoparticles was characterized with scanning electron microscopy (SEM) and the size and size distribution were determined by dynamic light scattering (DLS). SEM images and DLS results revealed that the particles were spherical in shape and about 100 nm in size

which was suitable for intravenous injection and close to the typically required size under physiological conditions. Thus

nanoparticles of P (LA-co-CA)-mPEG could be used as biodegradable

biocompatible

and cell-specific targetable nano-structured carriers for intracellular delivery of hydrophobic anticancer drugs.