Based on the single-stage model for chiral extraction of naproxen(NAP)enantiomers and the law of mass conservation

a model for multi-stage countercurrent centrifugal extraction of naproxen enantiomers was built.The model was programmed with Matlab and the influence of process parameters such as phase ratio

extractant concentration

pH value of aqueous phase was examined.Increase of phase ratio(W/O)reduces the enantiomeric excess(eeextract)and increases the yield(Yextract)in the extract. With the increase of extractant concentration

eeextract of extract increases quickly at first

then decreases slowly

and Yextract increases continuously.As pH increases

Yextract keeps increase

while eeextract decreases.The experimental and simulation studies indicate that eeextract of 45% and Yextract of 60% are achieved under the optimal separation conditions:R

S-NAP concentration of 0.025 mol·L-1

HP-β-CD concentration of 0.050 mol·L-1

phase ratio of 7

pH of 2.5

and temperature of 5℃.