Estimation and control of process time for membrane separation of cephalosporin C from fermentation broth

WANG Longyao; WANG Lan

doi:10.3969/j.issn.0438-1157.2013.09.025

您当前的位置：

首页 >

文章列表页 >

Estimation and control of process time for membrane separation of cephalosporin C from fermentation broth

更新时间：2025-12-10

- Estimation and control of process time for membrane separation of cephalosporin C from fermentation broth
- CIESC Journal Issue 9, Pages: 3256-3261(2013)
- 作者机构：
  
  常州大学石油化工学院, 江苏省精细石油化工重点实验室,江苏,常州,213164
- 作者简介：
- 基金信息：
- DOI：10.3969/j.issn.0438-1157.2013.09.025
  CLC： Q028.8TQ465.92
- Online First：05 September 2013，
  
  Published：05 September 2013
- 稿件说明：
移动端阅览
WANG Longyao, WANG Lan. Estimation and control of process time for membrane separation of cephalosporin C from fermentation broth[J]. CIESC Journal, 2013, (9): 3256-3261.
DOI：

WANG Longyao, WANG Lan. Estimation and control of process time for membrane separation of cephalosporin C from fermentation broth[J]. CIESC Journal, 2013, (9): 3256-3261. DOI： 10.3969/j.issn.0438-1157.2013.09.025.

摘要

针对头孢菌素C(CPC)发酵液在工业生产中难过滤的问题

在收率衡算模型基础上

结合浓差极化机理引入时间参数

针对连续洗滤过程(CFD)建立考虑时间的膜分离过程估算式

并以最短膜处理时间tmin为目标进行了优化求解。结果表明

在优化的膜处理过程中

CPC收率从85%增长到95%所用时间占总处理时间的30%～40%;而前浓缩比a值在0.5～0.8范围内时

总膜过滤时间差别不大。在一个相对较宽的可操作范围内

适当调整前浓缩比或/和调整目标收率

可以对生产过程的时效性及CPC收率、滤液/保留液体积等生产指标进行优化与控制。

Abstract

Cephalosporin C(CPC)fermentation broth is a typical material with high solid content and high viscosity.Under the condition of constant yield of CPC in filtrate

how to minimize the process time of membrane filtration is an interesting area in industrial applications.Based on the stagnant film theory and mass balance

the estimate equation is founded and the conditions to reach the minimum process time tmin are put forward.The results show that the time consumed is 30%—40% of the total process time when the yield of CPC is from 85% to 95%.Under the experiment conditions(pre-concentration ratio 0.5—0.8

post-concentration ratio 1)

the total filtration time is nearly the same.Based on the theoretical and experimental results

the production requirements as CPC yield

the volume of filtrate or retentate and the process effectiveness can be optimized and controlled properly.

关键词

Keywords

references

Views

264

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Model-assisted process optimization of ion-exchange chromatography for monoclonal antibody charge variant separation

Full-cycle optimization of acetylene conversion distribution for acetylene hydrogenation beds-in-series reactor

A coordinated optimal margin design method for chemical process based on relative gain and priority

Process simulation and economic evaluation of monoclonal antibody production

Optimization of crystallization process of fructose

Related Author

LIN Dongqiang

YAO Shanjing

WANG Haibin

GAO Dong

JIAO Jingyu

GAO Dan

CHEN Yucheng

XU Rufeng

Related Institution

Key Laboratory of Biomass Chemical Engineering of Ministry of Education, College of Chemical and Biological Engineering, Zhejiang University

Hisun Biopharmaceutical Co., Ltd.

Department of Automation, College of Information Science and Engineering, China University of Petroleum

Key Laboratory of Biomass Chemical Engineering of Ministry of Education, College of Chemical and Biological Engineering, Zhejiang University

Zhejiang Hisun Pharmaceutical Co., Ltd.

⁰