Fractal analysis of flexibility of enzyme active sites

PENG Xin; ZHANG Yuwei; WANG Mengfan; QI Wei; SU Rongxin; HE Zhimin

doi:10.3969/j.issn.0438-1157.2013.02.035

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Fractal analysis of flexibility of enzyme active sites

更新时间：2025-12-10

- Fractal analysis of flexibility of enzyme active sites
- CIESC Journal Issue 2, Pages: 671-675(2013)
- 作者机构：
  
  1. 天津大学化工学院,天津,300072
  2. 化学工程联合国家重点实验室,天津,300072
- 作者简介：
- 基金信息：
- DOI：10.3969/j.issn.0438-1157.2013.02.035
  CLC： 617Q811.4
- Online First：05 February 2013，
  
  Published：05 February 2013
- 稿件说明：
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PENG Xin, ZHANG Yuwei, WANG Mengfan, et al. Fractal analysis of flexibility of enzyme active sites[J]. CIESC Journal, 2013, (2): 671-675.
DOI：

PENG Xin, ZHANG Yuwei, WANG Mengfan, et al. Fractal analysis of flexibility of enzyme active sites[J]. CIESC Journal, 2013, (2): 671-675. DOI： 10.3969/j.issn.0438-1157.2013.02.035.

摘要

Abstract

Fractal geometry provides a mathematical formalism for describing complex spatial and dynamical structures.Therefore the enzyme molecules with irregular and self-similar structure can be studied thoroughly based on the fractal theory.In this paper the principle of box-counting dimension was used to investigate the impact of temperature and inhibitor on the structural changes of global enzymes and active sites of enzymes.The results suggested that the fractal dimension of enzyme molecule was greater than the fractal dimension of its active site.With increasing temperature

the calculated box-counting dimensions of global enzymes and their active sites all increased

especially for active sites.When enzyme was combined to the inhibitor

the dimensions of global enzymes did not change obviously

while the dimensions of active sites all decreased

indicating the decline of complexity for active sites.

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