Simulation of separation in continuous annular chromatography

LI Chengzhao; WU Kejing; QIN Wei; FEI Weiyang

doi:10.3969/j.issn.0438-1157.2013.02.022

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Simulation of separation in continuous annular chromatography

更新时间：2025-12-10

- Simulation of separation in continuous annular chromatography
- CIESC Journal Issue 2, Pages: 568-573(2013)
- 作者机构：
  
  清华大学化学工程系,化学工程联合国家重点实验室,北京,100084
- 作者简介：
- 基金信息：
- DOI：10.3969/j.issn.0438-1157.2013.02.022
  CLC： Q028.32
- Online First：05 February 2013，
  
  Published：05 February 2013
- 稿件说明：
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LI Chengzhao, WU Kejing, QIN Wei, et al. Simulation of separation in continuous annular chromatography[J]. CIESC Journal, 2013, (2): 568-573.
DOI：

LI Chengzhao, WU Kejing, QIN Wei, et al. Simulation of separation in continuous annular chromatography[J]. CIESC Journal, 2013, (2): 568-573. DOI： 10.3969/j.issn.0438-1157.2013.02.022.

摘要

连续环状色谱柱是有机物稀溶液及生物制品纯化的重要制备手段

为深入认识连续环状色谱柱的性能

开展了连续环状色谱柱分离性能模拟计算的研究。提出了二维空间网格差分的模拟计算方法

并采用文献报道的木糖-山梨糖分离的实验结果进行验证

模拟计算结果与实验数据基本吻合

证明了模拟计算方法的可行性。同时考察了单组分体系下进料流量、床层旋转速度、相间总传质系数、吸附平衡常数对流出曲线的影响;以木糖为分离关键组分

以木糖的收率和纯度为目标函数

对双组分体系下进料流量、床层旋转速度、床层高度、选择性系数对分离效果的影响进行了计算和讨论

结果表明

选择性系数是决定性因素

适当提高床层旋转速度或床层高度可以增大木糖的纯度。

Abstract

A 2-D-formulation of the mass balance equations for continuous annular chromatograph (CAC) is proposed.A numerical algorithm is developed to solve the coupled system of nonlinear convection diffusion equations in an iterative manner.The streamline diffusion method on an adaptively refined mesh is used to discretize the corresponding linear convection diffusion equations.The simulation with the mathematical model for CAC coincides with experimental data well.Profiles at the outlets in xylose-sorbose system show the robustness of the proposed algorithm over a wide range of design parameters.The model and algorithm are used to perform parametric calculations to investigate the influence of several model parameters on typical performance criteria for the chromatographic separation process.

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