Research progress of aptamer in biochemical separation and detection

LI Xiaopei; YANG Liangrong; HUANG Kun; LI Wensong; SUN Xitong; LIU Huizhou

doi:10.3969/j.issn.0438-1157.2013.01.025

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Research progress of aptamer in biochemical separation and detection

更新时间：2025-12-10

- Research progress of aptamer in biochemical separation and detection
- CIESC Journal Issue 1, Pages: 233-242(2013)
- 作者机构：
  
  1. 中国科学院过程工程研究所,中国科学院绿色过程与工程重点实验室,北京,100190
  2. 中国科学院研究生院,北京,100190
- 作者简介：
- 基金信息：
- DOI：10.3969/j.issn.0438-1157.2013.01.025
  CLC： Q937
- Online First：05 January 2013，
  
  Published：05 January 2013
- 稿件说明：
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LI Xiaopei, YANG Liangrong, HUANG Kun, et al. Research progress of aptamer in biochemical separation and detection[J]. CIESC Journal, 2013, (1): 233-242.
DOI：

LI Xiaopei, YANG Liangrong, HUANG Kun, et al. Research progress of aptamer in biochemical separation and detection[J]. CIESC Journal, 2013, (1): 233-242. DOI： 10.3969/j.issn.0438-1157.2013.01.025.

摘要

核酸适配体是一种能够特异性地识别目标物的寡聚核苷酸

可以是RNA也可以是DNA。较其他识别分子而言

适配体具有性质稳定、易合成、易标记、分子量较小和目标分子广泛等优势。目前核酸适配体主要被应用在检测、分离纯化和医疗三大领域

本文主要论述了适配体在生化分离及检测领域中的研究进展。

Abstract

Aptamers are short single stranded DNA or RNA oligonucleotides that exhibit high affinity and specificity to their corresponding targets.Compared to other recognition molecules

aptamers are highly stable

easier to synthesize and modify

smaller in size and specific to a wide range of targets.Until now

aptamers have shown diverse applications to detection

separation and purification studies

and development of medical treatment.This paper summarizes the research progress of aptamer in biochemical separation and detection.

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