Parameter estimation and cold model experiments of gastrointestinal simulation reactor

ZHANG Wenlong; ZHAN Xiaobei; CHEN Luo; ZHENG Zhiyong; ZHU Li; LI Zhitao; GAO Minjie

doi:10.11949/j.issn.0438-1157.20181488

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Parameter estimation and cold model experiments of gastrointestinal simulation reactor

Biochemical engineering and technology | 更新时间：2026-07-24

- Parameter estimation and cold model experiments of gastrointestinal simulation reactor
- CIESC Journal Vol. 70, Issue 5, Pages: 1879-1886(2019)
- 作者机构：
  
  1.江南大学生物工程学院糖化学与生物技术教育部重点实验室，江苏无锡 214122
  2.江南大学环境与土木工程学院，江苏无锡 214122
  3.无锡格莱克斯生物科技有限公司，江苏无锡 214125
- 作者简介：
- 基金信息：
- DOI：10.11949/j.issn.0438-1157.20181488
  CLC： TQ 027.6
- Received：18 December 2018，
  
  Revised：2019-02-15，
  
  Online First：24 July 2026，
  
  Published：05 May 2019
- 稿件说明：
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张文龙, 詹晓北, 陈荦, 郑志永, 朱莉, 李志涛, 高敏杰. 模拟胃肠道反应器的参数建立与冷模实验研究[J]. 化工学报, 2019, 70(5): 1879-1886

ZHANG Wenlong, ZHAN Xiaobei, CHEN Luo, ZHENG Zhiyong, ZHU Li, LI Zhitao, GAO Minjie. Parameter estimation and cold model experiments of gastrointestinal simulation reactor[J]. CIESC Journal, 2019, 70(5): 1879-1886
张文龙, 詹晓北, 陈荦, 郑志永, 朱莉, 李志涛, 高敏杰. 模拟胃肠道反应器的参数建立与冷模实验研究[J]. 化工学报, 2019, 70(5): 1879-1886 DOI： 10.11949/j.issn.0438-1157.20181488.

ZHANG Wenlong, ZHAN Xiaobei, CHEN Luo, ZHENG Zhiyong, ZHU Li, LI Zhitao, GAO Minjie. Parameter estimation and cold model experiments of gastrointestinal simulation reactor[J]. CIESC Journal, 2019, 70(5): 1879-1886 DOI： 10.11949/j.issn.0438-1157.20181488.

摘要

体外消化和发酵实验紧密结合才能模拟完整消化道的功能，现有的模拟胃肠消化和大肠发酵的反应器结构各异且不通用，组合多个独立反应器则增加了实验的复杂程度和设备成本。集成了两类反应器的优势特征，开发了一种采用可编程逻辑控制器（PLC）的模拟胃肠道反应器（GSR），模拟了整体的胃肠道动态特征并与体内数据进行了比较。结果表明模拟胃肠道反应器既可准确模拟胃和小肠的蠕动、排空和混合等动态特征，又可提供肠道微生物的发酵环境。尾气排放和收集装置的设计实现了尾气快速排出和尾气体积的准确计量。模拟胃肠道反应器可为体外探索益生元对肠道微生物作用等研究提供帮助。

Abstract

In vitro

digestion and fermentation experiments should be closely combined to simulate the function of the intact gastrointestinal tract. However

the existing simulated reactors for gastrointestinal digestion and large intestinal fermentation have different structures and are not universal. Combining the separated reactors would increase the complexity and the cost of the experiments. Integrated the dominant features of both types of reactors

a gastrointestinal simulation reactor(GSR) using a programmable logic controller(PLC) was developed in the present work. The dynamic characteristics of overall gastrointestinal tract were simulated and compared to the data

in vivo

. It shows that the developed reactor can accurately simulate the dynamic characteristics of peristalsis

emptying and mixing in the stomach and small intestine

and provide a fermentation environment for intestinal microbes. The exhaust gas discharge and collection device was considerately designed

the exhaust gas was quickly discharged and the volume could be accurately measured. The gastrointestinal simulation reactor can help to explore the role of prebiotics in intestinal microbes

in vitro

关键词

Keywords

references

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