Preparation and sustained release performance of 2,4-D/grafted CMC nanoparticles

QIU Songfa; XU Binhua; LIN Guanquan; ZHOU Xinhua; CHEN Huayao; ZHOU Hongjun

doi:10.11949/j.issn.0438-1157.20181292

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Preparation and sustained release performance of 2,4-D/grafted CMC nanoparticles

Material science and engineering\, nanotechnology | 更新时间：2026-07-24

- Preparation and sustained release performance of 2,4-D/grafted CMC nanoparticles
- CIESC Journal Vol. 70, Issue 5, Pages: 143016160-143016168(2019)
- 作者机构：
  
  仲恺农业工程学院化学化工学院，广东省普通高校农用绿色精细化学品重点实验室，广东广州 510225
- 作者简介：
- 基金信息：
- DOI：10.11949/j.issn.0438-1157.20181292
  CLC： TQ 450.6
- Received：02 November 2018，
  
  Revised：2019-01-29，
  
  Online First：24 July 2026，
  
  Published：05 May 2019
- 稿件说明：
移动端阅览
邱松发, 许斌华, 林冠权, 周新华, 陈铧耀, 周红军. 2,4-D/CMC接枝物纳米粒子的制备与缓释性能研究[J]. 化工学报, 2019, 70(5): 2007-2015

QIU Songfa, XU Binhua, LIN Guanquan, ZHOU Xinhua, CHEN Huayao, ZHOU Hongjun. Preparation and sustained release performance of 2,4-D/grafted CMC nanoparticles[J]. CIESC Journal, 2019, 70(5): 2007-2015
邱松发, 许斌华, 林冠权, 周新华, 陈铧耀, 周红军. 2,4-D/CMC接枝物纳米粒子的制备与缓释性能研究[J]. 化工学报, 2019, 70(5): 2007-2015 DOI： 10.11949/j.issn.0438-1157.20181292.

QIU Songfa, XU Binhua, LIN Guanquan, ZHOU Xinhua, CHEN Huayao, ZHOU Hongjun. Preparation and sustained release performance of 2,4-D/grafted CMC nanoparticles[J]. CIESC Journal, 2019, 70(5): 2007-2015 DOI： 10.11949/j.issn.0438-1157.20181292.

摘要

以羧甲基纤维素钠（CMC）为基材，甲基丙烯酸甲酯（MMA）和二甲基二烯丙基氯化铵（DMDAAC）为改性单体，通过乳液聚合制备了CMC-

-P(MMA-DMDAAC)共聚物，采用自组装方法负载2

4-二氯苯氧乙酸（2

4-D）得到2

4-D/CMC-

-P(MMA-DMDAAC)纳米药物缓释体系。利用傅里叶红外光谱（FTIR）、差示扫描量热法（DSC）、热重分析（TGA）、扫描电镜（SEM）、粒度分析仪对其结构和形貌进行表征，并探究其载药性能和缓释性能。结果表明，2

4-D/CMC-

-P(MMA-DMDAAC)载药粒子呈笼状结构，粒度分布为160～425 nm；其载药率随着CMC∶MMA∶DMDAAC的摩尔比增大而提高，最高可达40.8%；其药物累计释放率随CMC∶MMA∶DMDAAC的摩尔比增大而降低，其释放行为符合Weibull模型，遵循Fick扩散机理。

Abstract

CMC-

-P(MMA-DMDAAC) was prepared by emulsion copolymerization and trapping as well as encapsulation of 2

-D

via

self-assembly resulted in the formation of 2

4-D/CMC-

-PDMDAAC nanoparticles. Its structure and morphology were characterized by Fourier transform infrared spectroscopy (FTIR)

differential scanning calorimetry (DSC)

thermogravimetric analysis (TGA)

scanning electron (SEM) and dynamic light scattering (DLS). Furthermore

the encapsulation efficiency and sustained-release characteristics were investigated. The results demonstrated that the 2

4-D/CMC-

-P(MMA-DMDAAC) drug-loaded particles showed a cage structure with a particle size distribution from 160 nm to 425 nm. Moreover

the encapsulation efficiency increased as the molar ratio of monomers increased

which could reach up to 40.8%. In addition

the higher molar ratio of the monomers was

the lower cumulative release rate of the drug exhibited. Overall

the mechanism of release of 2

4-D from nanocarriers was consistent with Fickian behavior.

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references

Foo K Y , Hameed B H . Detoxification of pesticide waste via activated carbon adsorption process [J ] . Journal of Hazardous Materials , 2010 , 175 ( 1 / 2 / 3 ): 1 - 11 .

Aouada F A , de Moura M R , Orts W J , et al . Polyacrylamide and methylcellulose hydrogel as delivery vehicle for the controlled release of paraquat pesticide [J ] . Journal of Materials Science , 2010 , 45 ( 18 ): 4977 - 4985 .

Shegokar R , Müller R H . Nanocrystals: industrially feasible multifunctional formulation technology for poorly soluble actives [J ] . International Journal of Pharmaceutics , 2010 , 399 ( 1 / 2 ): 129 - 139 .

林粤顺 , 周红军 , 周新华 , 等 . pH响应性PAA/毒死蜱/氨基化介孔硅缓释体系的制备与性能 [J ] . 化工学报 , 2016 , 67 ( 10 ): 4500 - 4507 .

Lin Y S , Zhou H J , Zhou X H , et al . Preparation and properties of pH-responsive control release system of PAA/chlorpyrifos/amino functionalized mesoporoussilica [J ] . CIESC Journal , 2016 , 67 ( 10 ): 4500 - 4507 .

Patel S , Bajpai J , Saini R , et al . Sustained release of pesticide (cypermethrin) from nanocarriers: an effective technique for environmental and crop protection [J ] . Process Safety and Environmental Protection , 2018 , 117 : 315 - 325 .

Sun Y , Ma Y , Fang G , et al . Controlled pesticide release from porous composite hydrogels based on lignin and polyacrylic acid [J ] . BioResources , 2015 , 11 ( 1 ): 2361 - 2371 .

Liu Z , Qie R , Li W , et al . Preparation of avermectin microcapsules with anti-photodegradation and slow-release by the assembly of lignin derivatives [J ] . New J. Chem ., 2017 , 41 ( 8 ): 3190 - 3195 .

Xiang Y , Han J , Zhang G , et al . Efficient synthesis of starch-regulated porous calcium carbonate microspheres as a carrier for slow-release herbicide [J ] . ACS Sustainable Chem. Eng ., 2018 , 3 ( 6 ): 3649 - 3658 .

Wang Y , Wang A , Wang C , et al . Synthesis and characterization of emamectin-benzoate slow-release microspheres with different surfactants [J ] . Scientific Reports , 2017 , 7 ( 1 ): 12761 .

Yusoff S N M , Kamari A , Aljafree N F A . A review of materials used as carrier agents in pesticide formulations [J ] . International Journal of Environmental Science and Technology , 2016 , 13 ( 12 ): 2977 - 2994 .

Müller R H , Gohla S , Keck C M . State of the art of nanocrystals-special features, production, nanotoxicology aspects and intracellular delivery [J ] . European Journal of Pharmaceutics and Biopharmaceutics , 2011 , 78 ( 1 ): 1 - 9 .

Zhang M R , Xu H , Lang M D . Synthesize of carboxymethyl chitosan-graft-polycaprolactone (CMCS- g -PCL) and the preparation of micelles [J ] . Advanced Materials Research , 2015 , 1120 / 1121 : 909 - 914 .

Raafat A I , Eid M , El-Arnaouty M B . Radiation synthesis of superabsorbent CMC based hydrogels for agriculture applications [J ] . Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms , 2012 , 283 : 71 - 76 .

Qiu L , Shao Z , Yang M , et al . Study on effects of carboxymethyl cellulose lithium (CMC-Li) synthesis and electrospinning on high-rate lithium ion batteries [J ] . Cellulose , 2014 , 21 ( 1 ): 615 - 626 .

Benslimane A , Bahlouli I M , Bekkour K , et al . Thermal gelation properties of carboxymethyl cellulose and bentonite-carboxymethyl cellulose dispersions: rheological considerations [J ] . Applied Clay Science , 2016 , 132 / 133 : 702 - 710 .

Lohani A , Singh G , Bhattacharya S , et al . Tailored-interpenetrating polymer network beads of κ-carrageenan and sodium carboxymethyl cellulose for controlled drug delivery [J ] . Journal of Drug Delivery Science and Technology , 2015 , 31 : 53 - 64 .

Mansouri S , Khiari R , Bettaieb F , et al . Characterization of composite materials based on LDPE loaded with agricultural tunisian waste [J ] . Polymer Composites , 2015 , 36 ( 5 ): 817 - 824 .

南鹏林 , 张维磊 , 赵彦生 , 等 . 改性聚天冬氨酸 /聚丙烯酸 /羧甲基纤维素复合高吸水性树脂的制备及其性能 [J ] . 精细化工 , 2017 , 34 ( 7 ): 751 - 759 .

Nan P L , Zhang W L , Zhao Y S , et al . Synthesis and properties of modified poly(aspartic acid)/poly(acrylic acid)/carboxymethyl cellulose composite superabsorbent resins [J ] . Fine Chemicals , 2017 , 34 ( 7 ): 751 - 759 .

Li W , Zuo P , Xu D , et al . Tunable adsorption properties of bentonite/carboxymethyl cellulose- g -poly(2-(dimethylamino) ethyl methacrylate) composites towards anionic dyes [J ] . Chemical Engineering Research and Design , 2017 , 124 : 260 - 270 .

Chen H , Lin G , Zhou H , et al . Preparation of avermectin/grafted CMC nanoparticles and their sustained release performance [J ] . Journal of Polymers and the Environment , 2018 , 26 ( 7 ): 2945 - 2953 .

Chen H , Lin Y , Zhou H , et al . Synthesis and characterization of chlorpyrifos/copper(Ⅱ) schiff base mesoporous silica with pH sensitivity for pesticide sustained release [J ] . Journal of Agricultural and Food Chemistry , 2016 , 64 ( 43 ): 8095 - 8102 .

Mahdavinia G , Afzali A , Etemadi H , et al . Magnetic/pH-sensitive nanocomposite hydrogel based carboxymethyl cellulose- g -polyacrylamide/montmorillonite for colon targeted drug deliver [J ] . Nanomedicine Research Journal , 2017 , 2 ( 2 ): 111 - 122 .

Mantilla A , Tzompantzi F , Fernández J L , et al . Photodegradation of 2,4-dichlorophenoxyacetic acid using ZnAlFe layered double hydroxides as photocatalysts [J ] . Catalysis Today , 2009 , 148 ( 1 / 2 ): 119 - 123 .

王海洋 , 尹国强 , 冯光柱 , 等 . 羽毛角蛋白/CMC复合膜的制备及结构和性能 [J ] . 材料导报 , 2014 , 28 ( 8 ): 67 - 71 .

Wang H Y , Yin G Q , Feng G Z , et al . Preparation, structure and properties of blend films of feather keratin and sodium carboxy methyl cellulose [J ] . Materials Review , 2014 , 28 ( 8 ): 67 - 71 .

Pourjavadi A , Ghasemzadeh H , Mojahedi F . Swelling properties of CMC- g -poly (AAm- co -AMPS) superabsorbent hydrogel [J ] . Journal of Applied Polymer Science , 2009 , 113 ( 6 ): 3442 - 3449 .

Tan Q , Jiang R , Xu M , et al . Nanosized sustained-release pyridostigmine bromide microcapsules: process optimization and evaluation of characteristics [J ] . International Journal of Nanomedicine , 2013 , 8 : 737 - 745 .

Costa P , Sousa Lobo J M . Modeling and comparison of dissolution profiles [J ] . European Journal of Pharmaceutical Sciences , 2001 , 13 ( 2 ): 123 - 133 .

Costa F O , Sousa J J S , Pais A A C C , et al . Comparison of dissolution profiles of Ibuprofen pellets [J ] . Journal of Controlled Release , 2003 , 89 ( 2 ): 199 - 212 .

Guo W , Quan P , Fang L , et al . Sustained release donepezil loaded PLGA microspheres for injection: preparation, in vitro and in vivo study [J ] . Asian Journal of Pharmaceutical Sciences , 2015 , 10 ( 5 ): 405 - 414 .

Lagorce-Tachon A , Karbowiak T , Simon J , et al . Diffusion of oxygen through cork stopper: is it a Knudsen or a Fickian mechanism? [J ] . Journal of Agricultural and Food Chemistry , 2014 , 62 ( 37 ): 9180 - 9185 .

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