Continuous synthesis of anisole in microreactor system

Hanlin WANG; Deqiang WANG; Kai WANG; Guangsheng LUO

doi:10.11949/j.issn.0438-1157.20181246

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Continuous synthesis of anisole in microreactor system

Catalysis\, kinetics and reactors | 更新时间：2026-07-24

- Continuous synthesis of anisole in microreactor system
- CIESC Journal Vol. 70, Issue 3, Pages: 922-928(2019)
- 作者机构：
  
  1.清华大学化学工程系，化学工程联合国家重点实验室，北京 100084
  2.山东半岛卤水资源高值化绿色化综合利用工程;技术研究中心，山东潍坊 262700
- 作者简介：
- 基金信息：
- DOI：10.11949/j.issn.0438-1157.20181246
  CLC： TQ 025.5
- Received：22 October 2018，
  
  Revised：2018-12-28，
  
  Online First：24 July 2026，
  
  Published：05 March 2019
- 稿件说明：
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王瀚琳, 王德强, 王凯, 骆广生. 微反应器内苯甲醚连续合成[J]. 化工学报, 2019, 70(3): 922-928

WANG Hanlin, WANG Deqiang, WANG Kai, LUO Guangsheng. Continuous synthesis of anisole in microreactor system[J]. CIESC Journal, 2019, 70(3): 922-928
王瀚琳, 王德强, 王凯, 骆广生. 微反应器内苯甲醚连续合成[J]. 化工学报, 2019, 70(3): 922-928 DOI： 10.11949/j.issn.0438-1157.20181246.

WANG Hanlin, WANG Deqiang, WANG Kai, LUO Guangsheng. Continuous synthesis of anisole in microreactor system[J]. CIESC Journal, 2019, 70(3): 922-928 DOI： 10.11949/j.issn.0438-1157.20181246.

摘要

苯甲醚是一种重要的溶剂和有机合成中间体，以往通过间歇反应合成，存在生产效率低下、操作周期长等问题，亟需开发连续化的生产装置和技术。提出以苯酚钠水溶液和硫酸二甲酯为原料通过连续微反应器合成苯甲醚的方法。该方法利用微混合器和局部收缩的反应管道强化反应物的混合，在近似绝热的反应条件下快速完成反应过程。报道了苯酚钠浓度、反应物流量和反应物摩尔比对于微反应器内苯酚钠转化率和硫酸二甲酯利用率的影响规律。与文献报道的间歇反应进行了对比，揭示了微反应技术的优势。

Abstract

Anisole is an important solvent and organic synthesis intermediate. In the past

it was synthesized by batch reaction

which has problems such as low production efficiency and long operation cycle. A continuous synthesis device and technology for anisole is highly required. A continuous-flow microreaction method using sodium phenolate solution and dimethyl sulfate as reactants was proposed. The microreactor employs micromixer and locally constructive reaction tube to enhance reactant mixing and the reaction was carried out at approximately adiabatic condition. The influences of sodiumphenolate concentration

reactant flow rate and molar ratio of phenolatetodimethyl sulfate on the sodium phenolate conversion and dimethyl sulfate utility were reported. A comparison with the batch reaction in the literatures was provided to show the advantage of microreaction technology.

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references

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