Solubility and ternary phase diagram of azithromycin dihydrate in water-organic solvent

Xiaoxue CAO; Shaochang JI; Wenjie KUANG; Anping LIAO; Ping LAN; Jinyan ZHANG

doi:10.11949/j.issn.0438-1157.20180910

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Solubility and ternary phase diagram of azithromycin dihydrate in water-organic solvent

Thermodynamics | 更新时间：2026-07-24

- Solubility and ternary phase diagram of azithromycin dihydrate in water-organic solvent
- CIESC Journal Vol. 70, Issue 3, Pages: 817-829(2019)
- 作者机构：
  
  1.广西民族大学化学化工学院，广西多糖材料与改性重点实验室，广西高校化学与生物转化过程新技术重点实验室，广西南宁 530006
  2.广西烟草专卖局，广西南宁 530006
- 作者简介：
- 基金信息：
- DOI：10.11949/j.issn.0438-1157.20180910
  CLC： TQ 026.5
- Received：13 August 2018，
  
  Revised：2018-12-18，
  
  Online First：24 July 2026，
  
  Published：05 March 2019
- 稿件说明：
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曹小雪, 吉绍长, 匡雯婕, 廖安平, 蓝平, 张金彦. 阿奇霉素二水合物在水-有机溶剂中溶解度及三元相图测定[J]. 化工学报, 2019, 70(3): 817-829

CAO Xiaoxue, JI Shaochang, KUANG Wenjie, LIAO Anping, LAN Ping, ZHANG Jinyan. Solubility and ternary phase diagram of azithromycin dihydrate in water-organic solvent[J]. CIESC Journal, 2019, 70(3): 817-829
曹小雪, 吉绍长, 匡雯婕, 廖安平, 蓝平, 张金彦. 阿奇霉素二水合物在水-有机溶剂中溶解度及三元相图测定[J]. 化工学报, 2019, 70(3): 817-829 DOI： 10.11949/j.issn.0438-1157.20180910.

CAO Xiaoxue, JI Shaochang, KUANG Wenjie, LIAO Anping, LAN Ping, ZHANG Jinyan. Solubility and ternary phase diagram of azithromycin dihydrate in water-organic solvent[J]. CIESC Journal, 2019, 70(3): 817-829 DOI： 10.11949/j.issn.0438-1157.20180910.

摘要

采用静态法测定了293.15～323.15 K范围内，阿奇霉素二水合物在丙酮-水和异丙醇-水混合溶剂中的溶解度，并研究阿奇霉素在293.15、298.15、303.15及308.15 K温度下丙酮-水混合溶剂中转晶水活度，根据溶解度特性绘制丙酮-阿奇霉素-水三元相图，溶解度数据用Apelblat方程、

λh

方程和van’t Hoff方程进行关联。结果表明，阿奇霉素溶解度随着有机溶剂体积分数和温度的升高而增加，转晶水活度随温度的升高增大，阿奇霉素一水二水共存区域随温度的升高减小，Apelblat方程拟合效果更好，

≥0.988。

Abstract

The solubility of azithromycinin water+isopropanol and propanon

e+water solvent mixtures were measured at temperatures from 293.15 K to 323.15 K by an analytical method. The water activity of transformation at 293.15

298.15

303.15 and 308.15 K were measured

and the phase diagram of alcohol- azithromycin -water at that temperature was obtained through solubility property. The solubility data were correlated by the modified Apelblat equation

λh

equation and van’t Hoff equation. The results showed that the solubility of azithromycin dihydrate obviously increased with the increase of temperature and the volume fraction of isopropanol and propanone

and the water activity of transformation increased and the coexist area decreased with the increase of temperature. The modified Apelblat equation was the best choice in the correlation of the solubility data.

关键词

Keywords

references

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