Preparation of BaSO<sub>4</sub> nanoparticles in microchannel reactor and its application in multifunctional layers of medical slices

Feifei YE; Baodan ZHANG; Haibo JIN; Xiaoyan GUO; Guangxiang HE; Rongyue ZHANG; Qingyang GU; Suohe YANG

doi:10.11949/j.issn.0438-1157.20180779

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Preparation of BaSO₄ nanoparticles in microchannel reactor and its application in multifunctional layers of medical slices

Material science and engineering\, nanotechnology | 更新时间：2026-07-24

- Preparation of BaSO₄ nanoparticles in microchannel reactor and its application in multifunctional layers of medical slices
- CIESC Journal Vol. 70, Issue 3, Pages: 1179-1187(2019)
- 作者机构：
  
  1.北京石油化工学院化学工程学院，燃料清洁化及高效催化减排技术北京市重点实验室，北京 102617
  2.北京化工大学化学工程学院，北京 100029
- 作者简介：
- 基金信息：
- DOI：10.11949/j.issn.0438-1157.20180779
  CLC： TQ 027
- Received：10 July 2018，
  
  Revised：2018-12-18，
  
  Online First：24 July 2026，
  
  Published：05 March 2019
- 稿件说明：
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叶飞飞, 张宝丹, 靳海波, 郭晓燕, 何广湘, 张荣月, 谷庆阳, 杨索和. 微通道反应器合成纳米BaSO₄颗粒及其在干片多功能层上的应用[J]. 化工学报, 2019, 70(3): 1179-1187 DOI: 10.11949/j.issn.0438-1157.20180779.

YE Feifei, ZHANG Baodan, JIN Haibo, GUO Xiaoyan, HE Guangxiang, ZHANG Rongyue, GU Qingyang, YANG Suohe. Preparation of BaSO₄ nanoparticles in microchannel reactor and its application in multifunctional layers of medical slices[J]. CIESC Journal, 2019, 70(3): 1179-1187 DOI: 10.11949/j.issn.0438-1157.20180779.
叶飞飞, 张宝丹, 靳海波, 郭晓燕, 何广湘, 张荣月, 谷庆阳, 杨索和. 微通道反应器合成纳米BaSO₄颗粒及其在干片多功能层上的应用[J]. 化工学报, 2019, 70(3): 1179-1187 DOI: 10.11949/j.issn.0438-1157.20180779. DOI：

YE Feifei, ZHANG Baodan, JIN Haibo, GUO Xiaoyan, HE Guangxiang, ZHANG Rongyue, GU Qingyang, YANG Suohe. Preparation of BaSO₄ nanoparticles in microchannel reactor and its application in multifunctional layers of medical slices[J]. CIESC Journal, 2019, 70(3): 1179-1187 DOI: 10.11949/j.issn.0438-1157.20180779. DOI：

摘要

以BaCl

和Na

为原料，采用微通道反应器制备得到立方形纳米BaSO

颗粒，并通过SEM、XRD对其进行表征。考察了不同反应方式及微通道反应器结构、反应物体积流量、反应物浓度、反应温度、体积流量比对纳米BaSO

颗粒大小和形貌的影响。实验结果表明：25℃下，体积流量为2.5 ml/min，反应物浓度为0.1 mol/L，体积流量比为5是应用于淀粉酶医用干片多功能层的纳米BaSO

颗粒合成的最佳反应条件。与直接沉淀法相比，微通道反应器内制备出的纳米BaSO

颗粒形貌规整，最终得到产物粒径为25～55 nm。将所制备的BaSO

多功能层应用到淀粉酶医用干片中，颜色梯度明显，经反射光密度仪检测，信号值依次减小，且信号值变化曲线重复性、稳定性较好，说明制备的BaSO

颗粒可应用于淀粉酶体外诊断试剂中多功能层上。

Abstract

BaCl

and Na

were used as raw materials to prepare cubic nano-BaSO

particles by microchannel reactor

and characterized by SEM and XRD. The effects of different reaction methods and microchannel reactor structures

volume flows of reactants

the concentration

temperature

volume flow ratio on size and morphology of BaSO

nanoparticles were investigated. The suitable reaction condition applied to multifunctional layer of amylase medical dry film was obtained with volume flow of 2.5 ml/min

reactant concentration of 0.1 mol/L

the temperature of 25℃ and volume flow ratio of 5. At the same time

compared with the direct precipitation method

the nano-BaSO

particles prepared in the microchannel reactor had a regular morphology with particle size from 25 nm to 55 nm. The prepared BaSO

multi-functional layers were applied to the amylase medical slides with an obvious color gradient. The signal value decreased in turn using the densitometer

and the repeatability and stability of signal value curve were better

which indicated that the prepared BaSO

particles could be applied to the multi-functional layer of the amylase

in vitro

diagnostic reagent.

关键词

Keywords

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Preparation of BaSO4 nanoparticles in microchannel reactor and its application in multifunctional layers of medical slices

DOI：10.11949/j.issn.0438-1157.20180779

摘要

Abstract

关键词

Keywords

references

Preparation of BaSO₄ nanoparticles in microchannel reactor and its application in multifunctional layers of medical slices