Preparation and aggregation kinetics of nanostructured lipid carrier

WEI Yuan; LING Hui; ZHENG Cheng; MAO Taoyan; ZENG Zhaowen; PENG Siyu; XIAO Runhui

doi:10.11949/j.issn.0438-1157.20180472

您当前的位置：

首页 >

文章列表页 >

Preparation and aggregation kinetics of nanostructured lipid carrier

更新时间：2025-12-10

- Preparation and aggregation kinetics of nanostructured lipid carrier
- CIESC Journal Issue 10, Pages: 4427-4437(2018)
- 作者机构：
  
  1. 广州大学精细化工研究所,广东,广州,510006
  2. 广州科技职业技术学院,广东,广州,510550
- 作者简介：
- 基金信息：
- DOI：10.11949/j.issn.0438-1157.20180472
  CLC： Q46
- Online First：05 October 2018，
  
  Published：05 October 2018
- 稿件说明：
移动端阅览
WEI Yuan, LING Hui, ZHENG Cheng, et al. Preparation and aggregation kinetics of nanostructured lipid carrier[J]. CIESC Journal, 2018, (10): 4427-4437.
DOI：

WEI Yuan, LING Hui, ZHENG Cheng, et al. Preparation and aggregation kinetics of nanostructured lipid carrier[J]. CIESC Journal, 2018, (10): 4427-4437. DOI： 10.11949/j.issn.0438-1157.20180472.

摘要

采用高压均质法制备包覆二苯酮-3（BP-3）和对甲氧基肉桂酸辛酯（OMC）两种紫外线吸收剂的纳米结构脂质载体（NLC），并通过单因素实验探究了总油相含量、液体脂质用量、防晒剂含量、乳化剂种类及其用量对NLC粒径、ζ电位和包封率的影响，并优化了工艺配方。此外，还考察了电解质的种类、浓度以及乳化剂用量对NLC聚集行为的影响并建立了聚集动力学模型。结果表明，电解质的存在可以压缩胶体体系的双电层，导致ζ电位降低，加剧纳米粒之间的聚集结合。NLC样品在电解质NaCl和CaCl2存在下的临界聚沉浓度分别为538.2和95.8 mmol·L-1，且在CaCl2溶液中的聚集速度比NaCl溶液中更快，适量的乳化剂对维持NLC体系的稳定性具有重要作用。

Abstract

Nanostructured lipid carrier (NLC) coated with two sunscreens

benzophenone-3 (BP-3) and octyl methoxycinnamate (OMC)

was prepared by high pressure homogenization. The effects of the total oil content

liquid lipid content

sunscreen content

as well as the emulsifier type and dosage on the particle size

zeta potential and entrapment efficiency of NLC were investigated by single-factor experiments

and the technical formula was optimized. Moreover

the effects of electrolyte type and concentration as well as the amount of emulsifier on the aggregation behaviors of NLC were further investigated and the dynamic model was established. The results show that the electrolyte can compress the electric double layer of the colloid system and decrease the zeta potential

which also aggravate the aggregation and binding between the nanoparticles. The critical coagulation concentrations of NLC samples in the inorganic electrolyte solutions of NaCl and CaCl2 were 538.2 and 95.8 mmol·L-1

respectively. And the aggregation rate of NLC in the solution of CaCl2 is faster than that in NaCl solutions. Besides

the proper amount of the emulsifier is also helpful to maintain the stability of the NLC system.

关键词

Keywords

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Characteristic, structure, preparation and applications of soft and hard carbons

Molecular dynamics simulation of ionic liquid [bmim][Tf2N]

Kinetics of ethanol oxidation over Pt/ZSM-5 catalyst

A kinetic model based on TGA data for pyrolysis of Zhundong coal

Adsorption performance of ethylenediamine propionyl crosslinked chitosan microspheres to methyl orange

Related Author

LI Shuo

ZHAO Zhepeng

CUI Zhengwei

YUAN Guanming

XU Bin

Tao WANG

Xiangyang LIU

Maogang HE

Related Institution

The State Key Laboratory of Refractories and Metallurgy, Wuhan University of Science and Technology

The Key Laboratory of Hubei Province for Coal Conversion and New Carbon Materials, Wuhan University of Science and Technology

Key Laboratory of Thermo-Fluid Science and Engineering of Ministry of Education, Xi’an Jiaotong University, , Shaanxi

State Key Laboratory of Clean Energy Utilization, Zhejiang University

College of Chemical Engineering, Northwest University, Chemical Engineering Research Center of Ministry of Education for Advanced Use Technology of Shanbei Energy

⁰