Based on the Fluent platform

the gas-liquid two-phase flow of the sliding wall surface serpentine microchannel was numerically calculated by the CLSVOF method. The results of numerical simulation were in agreement with theoretical computation. At the same time

the slip phenomenon produced on hydrophobic surface was more significant in smaller microchannel which would reduce fluid flow resistance and achieve drag reduction. The calculation results of fluid flow in microchannel with different wall properties show that slip boundary has almost no effect on distribution of cross-section velocity. The location of maximum cross section velocity was influenced when contact angle of upper and lower wall was different. The contact angle and relative roughness had great effect on slip characteristics. Reasonable design of wall wettability and micro roughness element structure can maximize the drag reduction caused by slip phenomenon. Heat transfer effect was better in microchannel under boundary slip compared with no-slip surface. And it was enhanced with the increase of slip velocity.