Synthesis of magnetic nanoparticles with core-shell structure and its drug loading properties

JIA Shangning; CHANG Juanjuan; LI Ningbo; QIAO Jie

doi:10.11949/j.issn.0438-1157.20180305

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Synthesis of magnetic nanoparticles with core-shell structure and its drug loading properties

更新时间：2025-12-10

- Synthesis of magnetic nanoparticles with core-shell structure and its drug loading properties
- CIESC Journal Issue S1, Pages: 170-175(2018)
- 作者机构：
  
  山西医科大学基础医学院,山西,太原,030001
- 作者简介：
- 基金信息：
- DOI：10.11949/j.issn.0438-1157.20180305
  CLC： 614.811
- Online First：30 September 2018，
  
  Published：30 September 2018
- 稿件说明：
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JIA Shangning, CHANG Juanjuan, LI Ningbo, et al. Synthesis of magnetic nanoparticles with core-shell structure and its drug loading properties[J]. CIESC Journal, 2018, (S1): 170-175.
DOI：

JIA Shangning, CHANG Juanjuan, LI Ningbo, et al. Synthesis of magnetic nanoparticles with core-shell structure and its drug loading properties[J]. CIESC Journal, 2018, (S1): 170-175. DOI： 10.11949/j.issn.0438-1157.20180305.

摘要

利用化学交联法合成了壳聚糖改性的四氧化三铁磁性纳米复合物。通过透射电子显微镜（TEM）、傅里叶转换红外光谱（FTIR）、粒度分析仪（Nano-ZS）和振动样品磁强计（VSM）对该复合物的形貌、粒径、物相组成及磁性能进行了表征分析。表明该磁性纳米复合物具有核壳结构。再用超声法合成了阿霉素-壳聚糖修饰的磁性纳米包合物，用紫外-可见（UV-Vis）分光光度计检测了该复合物的包封率，平均值达到46.13%。通过四唑盐（MTT）比色法证明了包合物对K150细胞的生物抑制作用。以上结果表明，该磁性纳米复合物具有良好的生物相容性和载药活性。

Abstract

Chitosan modified magnetic nanocomposites were synthesized by the chemical cross linking method. Physicochemical properties including the morphology

phase composition

particle size and magnetic properties were characterized by TEM

FTIR

particle size analyzer and VSM. It was proved that the modified magnetic nanocomposites had corn-shell structure. The magnetic nanocomposites with adriamycin were synthesized by the ultrasonic method. The encapsulation efficiency of magnetic nanocomposites was analyzed by UV-Vis spectrophotometry

and the average entrapment efficiency was up to 46.13%

then further determined by MTT colorimetric method proved that the inclusion compound had obvious biological inhibition of K150 cells. The results showed that the magnetic nanomaterials had good biocompatibility and drug loading activity.

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