DMFA-based multi-objective optimization for fermentation processes

GAO Yan; ZHAO Zhonggai; LIU Fei

doi:10.11949/j.issn.0438-1157.20171496

您当前的位置：

首页 >

文章列表页 >

DMFA-based multi-objective optimization for fermentation processes

更新时间：2025-12-10

- DMFA-based multi-objective optimization for fermentation processes
- CIESC Journal Issue 6, Pages: 2594-2602(2018)
- 作者机构：
  
  江南大学轻工过程先进控制教育部重点实验室,江苏,无锡,214122
- 作者简介：
- 基金信息：
- DOI：10.11949/j.issn.0438-1157.20171496
  CLC： Q920
- Online First：05 June 2018，
  
  Published：05 June 2018
- 稿件说明：
移动端阅览
GAO Yan, ZHAO Zhonggai, LIU Fei. DMFA-based multi-objective optimization for fermentation processes[J]. CIESC Journal, 2018, (6): 2594-2602.
DOI：

GAO Yan, ZHAO Zhonggai, LIU Fei. DMFA-based multi-objective optimization for fermentation processes[J]. CIESC Journal, 2018, (6): 2594-2602. DOI： 10.11949/j.issn.0438-1157.20171496.

摘要

通过动态代谢通量分析方法建立发酵过程模型，提出了一种基于微观代谢信息的发酵过程多目标优化策略，该策略基于所建微观模型，根据动态特性将发酵过程分为菌体生长和产物合成两个阶段，进行特征分析并从微观通量层面分别设计优化目标与约束条件，采用多目标粒子群算法求得最优解。该方法用于青霉素发酵过程底物流加速率和pH的操作轨迹优化，仿真实验结果表明，采用基于微观通量的多目标优化策略能够提高产物终端浓度，表明优化策略的有效性。

Abstract

A multi-objective micro-scale optimization strategy for fermentation processes was proposed to achieve optimal operation on the basis of a dynamic metabolic flux analysis (DMFA) model. According to different dynamic characteristics

the strategy divided a fermentation process into two stages of cell growth and product synthesis

in which objective functions and constraints were designed from micro metabolic flux and pathways. Multi-objective particle swarm optimization (MOPSO) was employed as key algorithm to find operation trajectory. The strategy was applied to simulation of penicillin fermentation for optimizing acceleration rate of feed stock and pH trajectory. The results showed that terminal product concentration was increased by 3.26% and total feed amount was decreased by 0.6 L

indicating effectiveness of the strategy.

关键词

Keywords

references

Views

251

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Expression optimization of heterologous CYP450 enzyme promotes the synthesis of ursolic acid in engineering Saccharomyces cerevisiae

Effects of substitution of ER domains on the synthesis of eicosapentaenoic acid in Schizochytrium limacinum SR21

Estimation of microbial metabolic state based on hybrid cybernetic model

Carbon source analysis, mutagenesis and kinetics of Serratia marcescens producing prodigiosin

Sub-culturing of novel Blautia coccoides GA-1 and acetate synthesis from H2/CO2 in subcultures

Related Author

NA Xuemei

WANG Yu

JIANG Yaozhu

JIA Nan

WANG Ying

LI Chun

Ruixiong YANG

Xin ZHENG

Related Institution

Key Laboratory of Medical Molecule Science and Pharmaceutical Engineering, Ministry of Industry and Information Technology, School of Chemistry and Chemical Engineering, Beijing Institute of Technology

Key Laboratory for Industrial Biocatalysis, Ministry of Education, Department of Chemical Engineering, Tsinghua University

College of Chemistry and Chemical Engineering, Xiamen University

Fujian Collaborative Innovation Center for Exploitation and Utilization of Marine Biological Resources

The Key Laboratory for Chemical Biology of Fujian Province (Xiamen University)

⁰