HPLC was used to study the dynamic degradation of catalitaxol at different temperatures. Establishing the dynamic degradation model of catalitaxol in Endophyte FSN002

the effect of the temperature on the stability of catalitaxol was quantitatively analyzed. It was found that the thermal degradation of catalitaxol in Endophyte FSN002 was first-order reaction kinetics. The thermal degradation rate constant increased rapidly with increasing temperature

fitting the Arrhenius equation. The half-life of catalitaxol at 4℃ was 25 d and it was shortened to 6 d at 25 ℃

while it was only 14 h at 55℃. The model predicted that the half-life of catalitaxol would be only 3.7 h at 70℃. The rotary evaporation of catalitaxol from Endophyte FSN002 would cause substantial degradation and low yield

which was entirely consistent with the experimental verification.