Crystallization process and growth mechanism for spherical products of clopidogrel sulfate

WANG Haiyang; DU Yanni; LI Zhenfang; SONG Xiaopeng; TAN Duanming; GONG Junbo

doi:10.11949/j.issn.0438-1157.20151084

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Crystallization process and growth mechanism for spherical products of clopidogrel sulfate

更新时间：2025-12-10

- Crystallization process and growth mechanism for spherical products of clopidogrel sulfate
- CIESC Journal Issue 9, Pages: 3633-3639(2015)
- 作者机构：
  
  1. 天津大学化工学院化学工程联合国家重点实验室,天津,300072
  2. 天津化学化工协同创新中心,天津,300072
  3. 深圳信立泰药业股份有限公司,深圳,518102
- 作者简介：
- 基金信息：
- DOI：10.11949/j.issn.0438-1157.20151084
  CLC： Q463+.54
- Online First：05 September 2015，
  
  Published：05 September 2015
- 稿件说明：
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WANG Haiyang, DU Yanni, LI Zhenfang, et al. Crystallization process and growth mechanism for spherical products of clopidogrel sulfate[J]. CIESC Journal, 2015, (9): 3633-3639.
DOI：

WANG Haiyang, DU Yanni, LI Zhenfang, et al. Crystallization process and growth mechanism for spherical products of clopidogrel sulfate[J]. CIESC Journal, 2015, (9): 3633-3639. DOI： 10.11949/j.issn.0438-1157.20151084.

摘要

本文测定了硫酸氢氯吡格雷Ⅰ、Ⅱ晶型在仲丁醇中的溶解度

通过过程分析和优化

制备了纯Ⅰ晶型的硫酸氢氯吡格雷球形晶体。与非球形晶体比较

球形晶体在堆密度、流动性、粒度分布以及稳定性等方面均占优势。本文考察了不同温度、残留溶剂对硫酸氢氯吡格雷晶习与晶型的影响

研究了硫酸氢氯吡格雷球形结晶过程晶体的生长机理。

Abstract

The difference between solubility of clopidogrel sulfate form Ⅰ and form Ⅱ in 2-butanol was determined by dynamic method. Based on process analysis and optimization of clopidogrel sulfate crystallization in solutions

clopidogrel sulfate of form Ⅰ was acquired with spherical shape. Compared with the non-spherical products

the spherical one possesses advantages in bulk density

flow ability

size distribution and stability. The crystal habit and crystal form of products prepared at different temperatures and residual solvents were investigated

the kinetics and growth mechanism of the spherical crystallization process was studied.

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