Advances in production of important platform chemicals by bio-manufacturing based on systems biology and synthetic biology

YUAN Haibo; LI Jianghua; LIU Long; DU Guocheng; CHEN Jian

doi:10.11949/j.issn.0438-1157.20151042

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Advances in production of important platform chemicals by bio-manufacturing based on systems biology and synthetic biology

更新时间：2025-12-10

- Advances in production of important platform chemicals by bio-manufacturing based on systems biology and synthetic biology
- CIESC Journal Issue 1, Pages: 129-139(2016)
- 作者机构：
  
  江南大学生物工程学院,江苏,无锡,214122
- 作者简介：
- 基金信息：
- DOI：10.11949/j.issn.0438-1157.20151042
  CLC： 815
- Online First：05 January 2016，
  
  Published：05 January 2016
- 稿件说明：
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YUAN Haibo, LI Jianghua, LIU Long, et al. Advances in production of important platform chemicals by bio-manufacturing based on systems biology and synthetic biology[J]. CIESC Journal, 2016, (1): 129-139.
DOI：

YUAN Haibo, LI Jianghua, LIU Long, et al. Advances in production of important platform chemicals by bio-manufacturing based on systems biology and synthetic biology[J]. CIESC Journal, 2016, (1): 129-139. DOI： 10.11949/j.issn.0438-1157.20151042.

摘要

基于生物质资源的平台化学品制造

是解决目前石化资源枯竭和环境问题的重要措施

对经济社会的可持续发展具有重要意义。本文主要介绍了系统生物学和合成生物学在有机酸(琥珀酸、富马酸、L-苹果酸、葡萄糖二酸、丙酮酸、苯丙酮酸、α-酮戊二酸)以及其他平台化学品(2

5-呋喃二甲酸)生物制造中的应用

并展望了生物制造在平台化学品生产中的未来发展方向。

Abstract

Due to the limited amount of fossil fuels and global warming problem

bio-manufacturing based on renewable biomass has been paid more attention. In this review

the contribution of systems biology and synthetic biology in bio-manufacture of platform chemicals like organic acid such as succinate

fumarate

malate

glucaric acid

pyruvate

phenylpyruvic acid

α-ketoglutarate and other platform chemicals such as 2

5-furandicarboxylic acid are reviewed. Finally

the trends of bio-manufacture for platform chemical are prospected.

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