Progressively frozen condensation crystallization of oxiracetam

DU Shichao; LI Kangli; ZHANG Yu; GAO Zhifeng; WANG Chenguang; GUO Baisong; LI Daixi; TANG Weiwei; GONG Junbo

doi:10.11949/j.issn.0438-1157.20150903

您当前的位置：

首页 >

文章列表页 >

Progressively frozen condensation crystallization of oxiracetam

更新时间：2025-12-10

- Progressively frozen condensation crystallization of oxiracetam
- CIESC Journal Issue 9, Pages: 3563-3569(2015)
- 作者机构：
  
  1. 国家工业结晶工程技术研究中心,天津,300072
  2. 天津化学化工协同创新中心,天津,300072
  3. 石药集团欧意药业有限公司,河北,石家庄,050051
  4. 上海东富龙科技股份有限公司,上海,201109
  5. 上海理工大学,上海,200093
- 作者简介：
- 基金信息：
- DOI：10.11949/j.issn.0438-1157.20150903
  CLC： 799
- Online First：05 September 2015，
  
  Published：05 September 2015
- 稿件说明：
移动端阅览
DU Shichao, LI Kangli, ZHANG Yu, et al. Progressively frozen condensation crystallization of oxiracetam[J]. CIESC Journal, 2015, (9): 3563-3569.
DOI：

DU Shichao, LI Kangli, ZHANG Yu, et al. Progressively frozen condensation crystallization of oxiracetam[J]. CIESC Journal, 2015, (9): 3563-3569. DOI： 10.11949/j.issn.0438-1157.20150903.

摘要

奥拉西坦简单冻干往往导致所需时间长、产品质量差等问题

本文应用MS软件计算了山梨醇和奥拉西坦晶体各个晶面的相互作用能

结果表明山梨醇和奥拉西坦之间的相互作用能较小

实验也证明冻干过程中奥拉西坦晶型、晶习不受山梨醇影响。通过DSC和热台显微镜分析

奥拉西坦简单冻干问题的关键因素在于原预冻过程处方逐步冻凝产生的是玻璃态

不利于水分子升华干燥

因此本文提出奥拉西坦冻干过程的逐步冻凝结晶工艺

改变山梨醇的结晶状态

使各组分分别冻凝分离成微晶态

实验放大结果表明冻干所需时间大幅度缩短

产品质量得到很大提高。

Abstract

It is found that direct freeze-drying method is not applicable to oxiracetam because of long time and poor product quality. In this paper

MS software is used to calculate the molecular interactions between additive (sorbitol) and different crystal surfaces of oxiracetam. These values are very small and could be neglected. Experiments also show that the crystal form and morphology are independent of sorbitol in freeze-drying process. Analyzed by differential scanning calorimetry and hot-stage microscopy

glassy sate of oxiracetam prescription is identified during original prefreezing process

against sublimation of water molecules. Therefore

we propose a gradual congelation crystallization technology to change the crystal state of sorbitol

congeal every component and separate them in microcrystalline. According to results of larger scale experiments

this new technique greatly shortens the time required and improves the product quality.

关键词

Keywords

references

Views

158

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Recent advances in machine learning for modeling and control of crystallization processes

Pharmaceutical polymorph control by supramolecular gel

Mechanochemical strategy for controlling solid-solid phase transition of α, ω-alkanedicarboxylic acids

Intelligent monitoring of crystallization processes based on in situ imaging and image analysis

Dynamic prediction method of particle size distribution in ternary precursor crystallization process based on population balance equations

Related Author

YAN Yihang

MA Yuan

LIU Chenglin

YU Jianguo

ZHANG Qi

ZHANG Xiangyang

LIN Jiawei

ZHUO Zhi’ao

Related Institution

National Engineering Research Center for Integrated Utilization of Salt Lake Resources, East China University of Science and Technology

Engineering Research Center of Resource Process Engineering, Ministry of Education, East China University of Science and Technology

State Key Laboratory of Chemical Engineering and Low-carbon Technology, East China University of Science andTechnology

School of Chemical Engineering and Technology, State Key Laboratory of Chemical Engineering and Low-Carbon Technology, Tianjin University

Beijing Key Laboratory of Enze Biomass Fine Chemicals, College of New Materials and Chemical Engineering, Beijing Institute of Petrochemical Technology

⁰