The gas-liquid two-phase flow in the hydrodynamically focused microchannels was investigated via computational fluid dynamics (CFD) method. Film was formed in the micro-channels and the film formation process included three stages. Surface pressure
shear stress force and surface tension force were changed during the film formation process. The effects of two-phase pressure change on the two-phase flux and film thickness were investigated. The results of numerical simulation showed that the pressure changing had little influence with constant two-phase pressure ratio at 1
while changing the ratio showed the significant influence.