Preparation and characterization of highly stable hybrid organosilicacellulose derivative-based chiral stationary phase

LUO Fei; WENG Xilun; BAO Zongbi; YANG Yiwen; REN Qilong

doi:10.11949/j.issn.0438-1157.20150547

您当前的位置：

首页 >

文章列表页 >

Preparation and characterization of highly stable hybrid organosilicacellulose derivative-based chiral stationary phase

更新时间：2025-12-10

- Preparation and characterization of highly stable hybrid organosilicacellulose derivative-based chiral stationary phase
- CIESC Journal Issue 11, Pages: 4520-4525(2015)
- 作者机构：
  
  浙江大学化学工程与生物工程学院, 生物质化工教育部重点实验室,浙江,杭州,310027
- 作者简介：
- 基金信息：
- DOI：10.11949/j.issn.0438-1157.20150547
  CLC： 657.7
- Online First：05 November 2015，
  
  Published：05 November 2015
- 稿件说明：
移动端阅览
LUO Fei, WENG Xilun, BAO Zongbi, et al. Preparation and characterization of highly stable hybrid organosilicacellulose derivative-based chiral stationary phase[J]. CIESC Journal, 2015, (11): 4520-4525.
DOI：

LUO Fei, WENG Xilun, BAO Zongbi, et al. Preparation and characterization of highly stable hybrid organosilicacellulose derivative-based chiral stationary phase[J]. CIESC Journal, 2015, (11): 4520-4525. DOI： 10.11949/j.issn.0438-1157.20150547.

摘要

合成了含少量3-(三乙氧基硅)丙基氨基甲酸酯的纤维素3

5-二甲基苯基氨基甲酸酯衍生物(CDMPC)

并采用1

2-二(三乙氧基硅基)乙烷(BTSE)为偶联剂

通过溶胶-凝胶法成功制备得到新型硅基杂化手性固定相。该固定相的CDMPC含量达60%

在含有10%氯仿的流动相中保持良好的手性识别性能和机械强度。使用其拆分了多种手性化合物

拆分效果优于商品柱Chiralpak IB

其中对2

2-三氟-1-(9-蒽基)乙醇和反式二苯乙烯氧化物对映体的分离选择性分别达到2.99和2.48

表明该类硅基杂化类手性固定相在制备色谱领域中有潜在应用前景。

Abstract

Chiral chromatography plays an important role in obtaining optically pure enantiomers. The key to preparative chiral chromatography is the availability of chiral stationary phases (CSPs) with broad chiral recognition

high sample loading as well as solvent tolerance. In order to overcome the shortcoming of traditional coating-type or bonding-type cellulose-based CSPs

a novel hybrid CSP based on cellulose derivative bearing a small amount of 3-(triethoxysilyl)propyl groups was proposed

which was used to crosslink with bis(triethoxysilyl)ethane (BTSE) via a sol-gel reaction. The prepared stationary phase was then evaluated by HPLC. The experimental results indicated that the CSP showed excellent chiral recognition ability and could run steadily at back column pressure more than 2000 psi (1 psi 6894.76 Pa) with flow-rate up to 3 ml·min-1 in the mobile phase containing 10% chloroform. It was worth mentioning that the selectivity of 2

2-trifluoro-1-(9-anthryl)ethanol and trans-stilbene oxide up to 2.99 and 2.48 was achieved

respectively

confirming its excellent chiral recognition performance. In addition

the reported CSP showed a promising packing for application in preparative chromatography such as simulated moving bed chromatography.

关键词

Keywords

references

Views

186

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

A hybrid modeling and optimization strategy for sequential simulated moving bed

Adaptive modeling of simulated moving bed based on KELM-ANFIS

Robust optimization of process parameters of simulated moving bed based on equilibrium theory

Separation of evodiamine and rutaecarpine with simulated moving bed chromatography

Separation of guaifenesin enantiomers by asynchronous Varicol process

Related Author

LIU Pengpeng

WANG Zhiguo

LUAN Xiaoli

LIU Fei

CHEN Yuxiang

ZHAO Zhonggai

Peng WEI

Jun CHEN

Related Institution

Key Laboratory of Advanced Control for Light Industry Process of the Ministry of Education, Jiangnan University

College of Chemistry and Chemical Engineering, Xiamen University

State Key Laboratory of Chemical Engineering, East China University of Science and Technology

State Key Laboratory of Heavy Oil Processing, China University of Petroleum

College of Chemistry and Chemical Engineering, Taiyuan University of Technology

⁰