Synthesis of gramine using acidic ionic liquid as catalyst

ZHANG Die; PENG Xiaoming; LIU Bo; GUO Xiaoyan; CAO Qianming; CHAO Jianping

doi:10.11949/j.issn.0438-1157.20150160

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Synthesis of gramine using acidic ionic liquid as catalyst

更新时间：2025-12-10

- Synthesis of gramine using acidic ionic liquid as catalyst
- CIESC Journal Issue S1, Pages: 192-196(2015)
- 作者机构：
  
  北京石油化工学院化学工程学院,北京,102617
- 作者简介：
- 基金信息：
  
  supported by the National Natural Science Foundation of China (21406015).
- DOI：10.11949/j.issn.0438-1157.20150160
  CLC： Q0324
- Online First：30 June 2015，
  
  Published：30 June 2015
- 稿件说明：
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ZHANG Die, PENG Xiaoming, LIU Bo, et al. Synthesis of gramine using acidic ionic liquid as catalyst[J]. CIESC Journal, 2015, (S1): 192-196.
DOI：

ZHANG Die, PENG Xiaoming, LIU Bo, et al. Synthesis of gramine using acidic ionic liquid as catalyst[J]. CIESC Journal, 2015, (S1): 192-196. DOI： 10.11949/j.issn.0438-1157.20150160.

摘要

以1-甲基咪唑为原料

经1-溴丁烷N-烷基化

再与H2SO4进行阴离子交换得到酸性离子液体1-丁基-3-甲基咪唑硫酸氢盐([bmim]+ HSO4-)

并以此为催化剂研究了以吲哚为原料的芦竹碱的合成

收率可达81.6%

催化剂连续使用4次收率基本维持不变。研究结果表明

在芦竹碱的合成反应中离子液体催化剂相比质子酸催化

具有环境友好

催化活性可接受

可重复利用的优良性能。

Abstract

Acidic ionic liquid 1- butyl -3- methyl imidazole hydrogen sulfate ([bmim]+ HSO4-) was prepared by using 1- methyl imidazole as a starting material through alkylation by n-butyl bromide and anion exchange with H2SO4. The synthesis of gramine from indole was investigated by employing the ionic liquid as catalyst with the yield of 81.6%

and the catalyst can be used continuously 4 times with keeping the yield essentially unchanged. The results demonstrated that the ionic liquid catalyst has excellent performance of environmental friendly

and the catalytic activity is more acceptable

reusable than the proton acid catalyst.

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