Synthesis of MCC-g-PGMA by AGET ATRP in ionic liquids

YUAN Miao; TANG Erjun; DU Kaidi; LIU Hong; ZHOU Jian; LIU Shaojie; ZHAO Dishun

doi:10.11949/j.issn.0438-1157.20141846

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Synthesis of MCC-g-PGMA by AGET ATRP in ionic liquids

更新时间：2025-12-10

- Synthesis of MCC-g-PGMA by AGET ATRP in ionic liquids
- CIESC Journal Issue S1, Pages: 365-369(2015)
- 作者机构：
  
  河北科技大学化学与制药工程学院, 河北省药物化工工程技术中心,河北,石家庄,050018
- 作者简介：
- 基金信息：
- DOI：10.11949/j.issn.0438-1157.20141846
  CLC： TQ032.4}
- Online First：30 June 2015，
  
  Published：30 June 2015
- 稿件说明：
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YUAN Miao, TANG Erjun, DU Kaidi, et al. Synthesis of MCC-g-PGMA by AGET ATRP in ionic liquids[J]. CIESC Journal, 2015, (S1): 365-369.
DOI：

YUAN Miao, TANG Erjun, DU Kaidi, et al. Synthesis of MCC-g-PGMA by AGET ATRP in ionic liquids[J]. CIESC Journal, 2015, (S1): 365-369. DOI： 10.11949/j.issn.0438-1157.20141846.

摘要

在氯化1-烯丙基-3-甲基咪唑([AMIM]Cl)离子液体中

采用AGET ATRP技术

以VC为还原剂、CuBr2/乙二胺为催化体系

成功制备了微晶纤维素接枝聚甲基丙烯酸缩水甘油酯(MCC-g-PGMA)分子。研究表明:[AMIM]Cl对微晶纤维素有较好的溶解性

最佳反应条件为GMA/乙二胺/CuBr2/VC摩尔比为100:4:1:1

反应温度25℃

反应时间4 h

接枝效率可达54.56%

分子量分布较窄为1.48。通过FT-IR、TEM和SEM测试表明:成功合成了MCC-g-PGMA接枝共聚物分子

PGMA接枝微晶纤维素后表面形态变得粗糙

接枝共聚物在丙酮溶液中可自组装成150～200 nm的球形结构

在药物载体领域具有良好的应用潜能。

Abstract

The MCC-g-PGMA was synthesized by AGET ATRP in ionic liquid [AMIM]Cl. Vitamin C was used as the reducing agent and CuBr2/ethanediamine was the catalytic system. The experiment proved that microcrystalline cellulose can well dissolve in [AMIM]Cl. Optimum mole ratio of GMA/ethanediamine/ CuBr2/VC were attained at 100:4:1:1. The temperature and reaction time were 25℃ and 4 h. The grafting efficiency was as high as 54.56% and the distribution of molecular weight of MCC-g-PGMA was 1.48. FT-IR proved that the MCC-g-PGMA graft copolymer was successfully synthesized by AGET ATRP in [AMIM]Cl. SEM showed the surface of MCC was changed and became coarse after PGMA grafted to MCC. It has a perfect application potential in the field of drug carrier.

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