Research advances in metabolic control of succinic acid fermentation

WANG Le; NI Zifu; HUI Ming; WANG Jinshui

doi:10.11949/j.issn.0438-1157.20141332

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Research advances in metabolic control of succinic acid fermentation

更新时间：2025-12-10

- Research advances in metabolic control of succinic acid fermentation
- CIESC Journal Issue 4, Pages: 1243-1251(2015)
- 作者机构：
  
  河南工业大学生物工程学院,河南,郑州,450001
- 作者简介：
- 基金信息：
- DOI：10.11949/j.issn.0438-1157.20141332
  CLC： 599
- Online First：05 April 2015，
  
  Published：05 April 2015
- 稿件说明：
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WANG Le, NI Zifu, HUI Ming, et al. Research advances in metabolic control of succinic acid fermentation[J]. CIESC Journal, 2015, (4): 1243-1251.
DOI：

WANG Le, NI Zifu, HUI Ming, et al. Research advances in metabolic control of succinic acid fermentation[J]. CIESC Journal, 2015, (4): 1243-1251. DOI： 10.11949/j.issn.0438-1157.20141332.

摘要

琥珀酸作为一种重要的化工原料被广泛应用于现代工业的各个领域

具有庞大的市场需求。利用生物法发酵生产琥珀酸因具有资源可再生利用、绿色清洁节能等方面不可替代的优势而成为当今研究的热点。本文从代谢调控的角度出发分析总结了一些产琥珀酸菌株

尤其是重组大肠杆菌在发酵生产琥珀酸中所应用到的方法和策略

如对代谢途径中关键酶的调控以及发酵生产中的关键因素(如氧化还原回复力调控、CO2调节、代谢途径改造等)

着重突出了代谢控制发酵生产方面的研究进展

并对今后的发展方向提出了一些设想。

Abstract

As an important chemical raw material

succinic acid is widely used in many fields of modern industry with a huge market demand. Recently

the biological method for succinic acid fermentation has become a hot topic in research

since it has the advantages of renewable utilization of resources and environmental friendly production. From the perspective of metabolic control

the methods and strategies for succinic acid production with some strains

especially the recombinant E.coli

are summarized in this paper. Regulation of key enzyme gene in metabolism branch and the key factors in fermentation of succinic acid

such as regulation of redox force

carbon dioxide control

and metabolic pathways transforming are introduced. The progress of metabolic control of succinic acid fermentation is presented

and development of succinic acid fermentation in the future is proposed.

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