Lignin biological funneling drives green synthesis of aromatic chemicals

YANG Jingru; WANG Yujia; LIU Zhihua

doi:10.11949/0438-1157.20260816

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Lignin biological funneling drives green synthesis of aromatic chemicals

更新时间：2026-07-22

- Lignin biological funneling drives green synthesis of aromatic chemicals
- CIESC Journal (2026)
- 作者机构：
  
  1.合成生物技术全国重点实验室, 天津300072
  2.天津大学合成生物与生物制造学院, 天津300072
- 作者简介：
- 基金信息：
- DOI：10.11949/0438-1157.20260816
  CLC： TQ 353
- Received：13 June 2026，
  
  Revised：2026-07-21，
  
  Accepted：22 July 2026，
- 稿件说明：
移动端阅览
YANG Jingru, WANG Yujia, LIU Zhihua. Lignin biological funneling drives green synthesis of aromatic chemicals[J/OL]. CIESC Journal, 2026.
DOI：

YANG Jingru, WANG Yujia, LIU Zhihua. Lignin biological funneling drives green synthesis of aromatic chemicals[J/OL]. CIESC Journal, 2026. DOI： 10.11949/0438-1157.20260816.

摘要

木质素作为自然界储量最丰富的可再生芳香聚合物，木质素“生物漏斗”路线通过多酶级联将结构各异的木质素解聚产物定向汇聚为少数或者单一平台化合物。系统综述了基于“生物漏斗”策略的木质素生物转化研究进展，重点阐述了香兰素、原儿茶酸、对羟基苯乙烯等芳香化学品的合成途径与工程化策略，并讨论了合成生物学、人工智能辅助酶工程和代谢调控等前沿技术在推动木质素生物转化应用中的关键作用。该综述有望为木质素生物转化合成高价值产物提供基础理论和关键技术支撑。

Abstract

Lignin

as the most abundant renewable aromatic polymer in nature. The “biological funnel” pathway directs structurally diverse depolymerization products into a few platform compounds via multi-enzyme cascade. Recent advances in lignin valorization based on the biological funnel strategy are systematically reviewed

with an emphasis on the biosynthetic routes and engineering strategies for aromatic chemicals such as vanillin

protocatechuic acid

and 4-hydroxystyrene. Furthermore

the applications of synthetic biology

artificial intelligence

and enzyme engineering in pathway reconstruction and key enzyme modification are analyzed. To address challenges such as product toxicity and the low conversion efficiency of S-type monomers

future directions including adaptive evolution

intelligent enzyme design

and full-chain synergistic conversion are discussed. This review provides theoretical guidance and a technical reference for the systematic engineering of lignin biological funnel pathways.

关键词

Keywords

references

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