Bridging gap between chemo- and biocatalysis: strategies and applications

LUAN Pengqian; ZHOU Dandan; WANG Xiaotian; CHEN Ran; GAO Shiqi; ZHAO Hao; HUANG Chen; LIU Yunting; GAO Jing; JIANG Yanjun

doi:10.11949/0438-1157.20200711

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Bridging gap between chemo- and biocatalysis: strategies and applications

Reviews and monographs | 更新时间：2026-07-24

- Bridging gap between chemo- and biocatalysis: strategies and applications
- CIESC Journal Vol. 71, Issue 12, Pages: 5361-5375(2020)
- 作者机构：
  
  1.河北工业大学化工学院，天津 300130
  2.河北工业大学化工节能过程集成与资源利用国家地方联合工程实验室，天津 300130
- 作者简介：
- 基金信息：
- DOI：10.11949/0438-1157.20200711
  CLC： O 62;Q 814
- Received：05 June 2020，
  
  Revised：2020-07-22，
  
  Online First：17 December 2020，
  
  Published：05 December 2020
- 稿件说明：
移动端阅览
栾鹏仟, 周丹丹, 王晓天, 陈冉, 高士耆, 赵浩, 黄琛, 刘运亭, 高静, 姜艳军. 架起化学-酶催化之间的桥梁：构建策略及催化应用[J]. 化工学报, 2020, 71(12): 5361-5375

LUAN Pengqian, ZHOU Dandan, WANG Xiaotian, CHEN Ran, GAO Shiqi, ZHAO Hao, HUANG Chen, LIU Yunting, GAO Jing, JIANG Yanjun. Bridging gap between chemo- and biocatalysis: strategies and applications[J]. CIESC Journal, 2020, 71(12): 5361-5375
栾鹏仟, 周丹丹, 王晓天, 陈冉, 高士耆, 赵浩, 黄琛, 刘运亭, 高静, 姜艳军. 架起化学-酶催化之间的桥梁：构建策略及催化应用[J]. 化工学报, 2020, 71(12): 5361-5375 DOI： 10.11949/0438-1157.20200711.

LUAN Pengqian, ZHOU Dandan, WANG Xiaotian, CHEN Ran, GAO Shiqi, ZHAO Hao, HUANG Chen, LIU Yunting, GAO Jing, JIANG Yanjun. Bridging gap between chemo- and biocatalysis: strategies and applications[J]. CIESC Journal, 2020, 71(12): 5361-5375 DOI： 10.11949/0438-1157.20200711.

摘要

化学-酶级联催化结合了化学催化的广泛反应性与生物催化的高选择性，是不对称合成高附加值手性化合物的有效途径。然而，化学催化剂和酶之间以及它们反应条件之间的不相容性极大地限制了这一领域的发展。因此设计可行的方法解决这些问题，实现两种催化范畴的兼容和优势互补，将使化学-酶级联催化反应得到更广泛的应用。综述了近年来克服化学催化与酶催化不相容性所采取的一些策略以及相关的研究进展，如时间分隔、空间分隔和集成催化剂等，并介绍了化学-酶级联催化在手性化合物动态动力学拆分及手性药物合成方面的应用，最后展望了该领域未来的局限性和发展趋势。

Abstract

The chemoenzymatic cascade catalysis combines the broad reactivity of chemical catalysis with the high selectivity of biocatalysis

and is an effective way to asymmetrically synthesize high value-added chiral compounds. However

the incompatibilities between the chemo- and biocatalysts as well as between their respective reaction conditions greatly restricted the development of this field. The design of feasible approaches to solve these problems can achieve the compatibility and complementary advantages of the two catalytic categories

thus making the chemoenzymatic cascade catalytic reactions more widely applied. In this review

the recent progress in developing strategies to overcome the incompatibility between chemical catalysis and enzymatic catalysis

such as temporal separation

spatial separation and integrated catalysts

is reviewed. The applications of chemoenzymatic cascade catalysis in dynamic kinetic resolution of chiral compounds and synthesis of chiral drugs are also introduced. Finally

the future limitations and the development trends of this field are prospected.

关键词

Keywords

references

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