Granulation of spherical particles by crystal agglomeration method

YU Changyou; HE Bingbing; LIU Yanbo; HOU Baohong; CHEN Mingyang; GONG Junbo

doi:10.11949/0438-1157.20200668

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Granulation of spherical particles by crystal agglomeration method

Celebration Column for School of Chemistry and Chemical Engineering\, Nanjing University | 更新时间：2026-07-24

- Granulation of spherical particles by crystal agglomeration method
- CIESC Journal Vol. 71, Issue 11, Pages: 4903-4917(2020)
- 作者机构：
  
  1.天津大学化工学院，化学工程联合国家重点实验室，天津 300072
  2.中低品位磷矿及其共伴生资源高效利用国家重点实验室，贵州贵阳 550500
  3.青海民族大学化学化工学院，青海西宁 810007
- 作者简介：
- 基金信息：
- DOI：10.11949/0438-1157.20200668
  CLC： TQ 028.5
- Received：29 May 2020，
  
  Revised：2020-07-05，
  
  Online First：03 November 2020，
  
  Published：05 November 2020
- 稿件说明：
移动端阅览
余畅游, 何兵兵, 刘岩博, 侯宝红, 陈明洋, 龚俊波. 制造球形粒子的晶体聚结方法[J]. 化工学报, 2020, 71(11): 4903-4917

YU Changyou, HE Bingbing, LIU Yanbo, HOU Baohong, CHEN Mingyang, GONG Junbo. Granulation of spherical particles by crystal agglomeration method[J]. CIESC Journal, 2020, 71(11): 4903-4917
余畅游, 何兵兵, 刘岩博, 侯宝红, 陈明洋, 龚俊波. 制造球形粒子的晶体聚结方法[J]. 化工学报, 2020, 71(11): 4903-4917 DOI： 10.11949/0438-1157.20200668.

YU Changyou, HE Bingbing, LIU Yanbo, HOU Baohong, CHEN Mingyang, GONG Junbo. Granulation of spherical particles by crystal agglomeration method[J]. CIESC Journal, 2020, 71(11): 4903-4917 DOI： 10.11949/0438-1157.20200668.

摘要

球形聚结技术能够在同一单元操作中耦合结晶和造粒过程以制备球形晶体。相比于传统流化床造粒技术，该技术具有工艺流程短，生产成本低，产品性能优良的优势，但是同时也面临研究方法不成熟、机理复杂、工业放大和特殊结晶器型等方面的挑战。总结了针对球形结晶产品的表征技术和关键产品指标，介绍了球形聚结过程机理、数学模型和新技术设备的研究进展，并提出关于深化机理、完善模型、开发新设备方面的新思路，最后对其在工业生产尤其是制药领域的发展进行了展望。

Abstract

Spherical agglomeration technology can prepare spherical agglomerates by coupling crystallization and granulation in a same unit operation

which has the advantages of short process

low production costs and excellent product performance compared with the traditional fluidized bed granulation technology. However

it is still challenging in characterization

mechanism

industrial scale-up

and special crystallizer type. Based on this

this article summarized the characterization techniques and key indicators of spherical crystallization products and mainly introduced the progress of mechanism

mathematical models

new technology and equipment of spherical agglomeration with new ideas for future research and development. Finally

it prospects the development in industrial production

especially in the pharmaceutical field.

关键词

Keywords

references

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