Recent advances of numbering-up technology of micro-dispersion devices

Yongjin CUI; Yankai LI; Kai WANG; Jian DENG; Guangsheng LUO

doi:10.11949/0438-1157.20200561

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Recent advances of numbering-up technology of micro-dispersion devices

Reviews and monographs | 更新时间：2025-11-25

- Recent advances of numbering-up technology of micro-dispersion devices
- CIESC Journal Vol. 71, Issue 10, Pages: 4350-4364(2020)
- 作者机构：
  
  清华大学化学工程系，化学工程联合国家重点实验室，北京 100084
- 作者简介：
- 基金信息：
- DOI：10.11949/0438-1157.20200561
  CLC： TQ 021.1
- Received：11 May 2020，
  
  Revised：2020-07-07，
  
  Published：05 October 2020
- 稿件说明：
移动端阅览
崔永晋, 李严凯, 王凯, 邓建, 骆广生. 微分散设备数量放大方式研究进展[J]. 化工学报, 2020, 71(10): 4350-4364

CUI Yongjin, LI Yankai, WANG Kai, DENG Jian, LUO Guangsheng. Recent advances of numbering-up technology of micro-dispersion devices[J]. CIESC Journal, 2020, 71(10): 4350-4364
崔永晋, 李严凯, 王凯, 邓建, 骆广生. 微分散设备数量放大方式研究进展[J]. 化工学报, 2020, 71(10): 4350-4364 DOI： 10.11949/0438-1157.20200561.

CUI Yongjin, LI Yankai, WANG Kai, DENG Jian, LUO Guangsheng. Recent advances of numbering-up technology of micro-dispersion devices[J]. CIESC Journal, 2020, 71(10): 4350-4364 DOI： 10.11949/0438-1157.20200561.

摘要

单分散液滴是生产球形颗粒和微胶囊的模板，相关材料广泛用于光学显示、药物递送、生物测定、食品加工等领域。微分散技术通过精确控制微米级通道内的多相流体流动获得尺寸小、粒径分布窄、结构复杂可控的微液滴，是一种公认的新方法。但由于单个微通道的低生产率，其大规模的工业和商业应用受到限制。为了实现产品的高通量、易控制的规模化生产，将大量液滴生成单元和流体分配通道网络并行到单个芯片上进行数量放大是微分散设备放大的基本模式。为了保持液滴的单分散性和设备的鲁棒性，流体在并联微通道内的均匀分布是关键科学问题。系统综述了微分散设备数量放大的最新进展，对加工技术和材料进行了相关分析，并在此基础上对微分散设备放大的未来研究方向进行展望。

Abstract

Monodisperse droplets are templates for producing spherical particles and microcapsules

and related materials are widely used in optical display

drug delivery

bioassay

food processing and other fields. Micro-dispersion technology is a recognized new method to obtain microdroplets with tiny size

narrow particle size distribution and controllable structure by accurately controlling the multiphase flow in microchannels. However

due to the low throughput of a single microchannel

its large-scale industrial and commercial applications are seriously limited. To achieve high-throughput and easy-to-control production

it is the basic numbering-up strategy of micro-dispersion devices by parallelizing a large number of microdroplet generators and the network of fluid distribution channels onto a single chip. To maintain the monodispersity of droplets and the robustness of device

the uniform distribution of fluid in parallel microchannels is a key scientific issue. This paper systematically reviews the recent progress in the numbering-up technology of micro-dispersion devices. The manufacturing technologies and materials are analyzed. On this basis

the future research directions of numbering-up of micro-dispersion devices are prospected.

关键词

Keywords

references

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