Application of synthetic biology in manufacture of bio-based plastics

Yanqin XU; Xizhi YANG; Ruoshi LUO; Yuhong HUANG; Feng HUO; Dan WANG

doi:10.11949/0438-1157.20200214

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Application of synthetic biology in manufacture of bio-based plastics

Reviews and monographs | 更新时间：2025-11-25

- Application of synthetic biology in manufacture of bio-based plastics
- CIESC Journal Vol. 71, Issue 10, Pages: 4520-4531(2020)
- 作者机构：
  
  1.重庆大学化学化工学院，化工过程强化与反应国家地方联合工程实验室，重庆 400044
  2.中国科学院过程工程研究所，北京 100190
- 作者简介：
- 基金信息：
- DOI：10.11949/0438-1157.20200214
  CLC： TK 6
- Received：02 March 2020，
  
  Revised：2020-04-25，
  
  Published：05 October 2020
- 稿件说明：
移动端阅览
徐彦芹, 杨锡智, 罗若诗, 黄玉红, 霍锋, 王丹. 合成生物学在生物基塑料制造中的应用[J]. 化工学报, 2020, 71(10): 4520-4531

XU Yanqin, YANG Xizhi, LUO Ruoshi, HUANG Yuhong, HUO Feng, WANG Dan. Application of synthetic biology in manufacture of bio-based plastics[J]. CIESC Journal, 2020, 71(10): 4520-4531
徐彦芹, 杨锡智, 罗若诗, 黄玉红, 霍锋, 王丹. 合成生物学在生物基塑料制造中的应用[J]. 化工学报, 2020, 71(10): 4520-4531 DOI： 10.11949/0438-1157.20200214.

XU Yanqin, YANG Xizhi, LUO Ruoshi, HUANG Yuhong, HUO Feng, WANG Dan. Application of synthetic biology in manufacture of bio-based plastics[J]. CIESC Journal, 2020, 71(10): 4520-4531 DOI： 10.11949/0438-1157.20200214.

摘要

合成生物学是以工程学思想为指导，对天然生物基因组进行改造和重构，合成新的生物元件，构建新的代谢途径，生产新产品或获得新表型的新兴学科。生物基塑料是以天然物质为原料在微生物作用或化学反应下生成的塑料。利用合成生物学改造工程菌株的方法制备合成生物基塑料已经成为学术界和产业界关注的热点。本文综述了合成生物学的发展和重要的合成生物学技术，重点综述了利用合成生物学技术构建聚羟基烷酸酯、尼龙、聚乳酸和丁二酸丁二醇酯等生物基塑料聚合物单体及其衍生物的代谢途径和工程优化领域的研究进展。

Abstract

Synthetic biology is a new discipline that uses engineering ideas as a guide to transform and reconstruct natural biological genomes

synthesize new biological components

construct new metabolic routes

and produce novel products or obtain new phenotypes. Bio-based plastics are plastics produced under the action of microorganisms or the chemical reactions using natural materials as raw materials. The usage of synthetic biology to construct engineered strains to produce bio-based plastics has become a hot topic in academia and industry. This paper reviews the development of synthetic biology and important techniques in the field of synthetic biology

focusing on the research progress in the field of metabolic pathways and engineering optimization for the construction of bio-based plastic polymer monomers and derivatives such as polyhydroxyalkanoate

nylon

polylactic acid

and butylene glycol succinate using synthetic biological techniques.

关键词

Keywords

references

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