Determination of solubility of steviol glycoside and rebiana as natural sweeteners in different solvents

YAN Hao; YAN Weidong

doi:10.11949/0438-1157.20191341

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Determination of solubility of steviol glycoside and rebiana as natural sweeteners in different solvents

Thermodynamics | 更新时间：2026-07-24

- Determination of solubility of steviol glycoside and rebiana as natural sweeteners in different solvents
- CIESC Journal Vol. 71, Issue 1, Pages: 231-236(2020)
- 作者机构：
  
  1. 杭州天草科技有限公司，浙江杭州 310004
  2. 浙江大学化学系，浙江杭州 310027
- 作者简介：
- 基金信息：
- DOI：10.11949/0438-1157.20191341
  CLC： O 645.12
- Received：06 November 2019，
  
  Revised：2019-11-18，
  
  Online First：12 August 2020，
  
  Published：05 January 2020
- 稿件说明：
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阎昊, 阎卫东. 两种天然甜味剂甜菊苷和瑞鲍迪苷A在不同溶剂中的溶解度测定[J]. 化工学报, 2020, 71(1): 231-236

YAN Hao, YAN Weidong. Determination of solubility of steviol glycoside and rebiana as natural sweeteners in different solvents[J]. CIESC Journal, 2020, 71(1): 231-236
阎昊, 阎卫东. 两种天然甜味剂甜菊苷和瑞鲍迪苷A在不同溶剂中的溶解度测定[J]. 化工学报, 2020, 71(1): 231-236 DOI： 10.11949/0438-1157.20191341.

YAN Hao, YAN Weidong. Determination of solubility of steviol glycoside and rebiana as natural sweeteners in different solvents[J]. CIESC Journal, 2020, 71(1): 231-236 DOI： 10.11949/0438-1157.20191341.

摘要

用高效液相色谱（HPLC）法测定了两种天然甜味剂甜菊苷和瑞鲍迪苷A在不同纯溶剂中的固液平衡数据，温度范围为288.15~328.15 K。从实验数据知，所有研究的体系的溶解度均随温度的升高而增大。实验数据用三参数方程和NRTL模型拟合，拟合结果显示，两种模型均有好的拟合结果。由得到的溶解度数据，可指导甜菊苷与瑞鲍迪苷A的分离及结晶纯化溶剂的选择。

Abstract

The solid-liquid equilibrium data of two natural sweeteners

stevioside and rebiana

in different pure solvents were determined by high performance liquid chromatography (HPLC) at a temperature range of 288.15—328.15 K. From the experimental data

it was found that the solubility increased with the rising temperature in all studied solvents. The obtained values for the solubility of steviol glycoside and rebiana in pure solvents were correlated with the three-parameter equation and NRTL models. The results showed that two models can accurately correlate the solubility data obtained in this work. According to the solubility data obtained

the separation of steviol glycoside and rebiana and the selection of solvent for crystallization and purification are guided. According to the solubility data obtained

the separation of steviol glycoside and rebiana and the selection of solvent for crystallization and purification are guided.

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references

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