Recent developments in enzymatic reactive distillation coupling technology

WANG Qinglian; WANG Xiaoda; WANG Hongxing; HUANG Zhixian; YE Changshen; QIU Ting

doi:10.11949/0438-1157.20191232

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Recent developments in enzymatic reactive distillation coupling technology

Reviews and monographs | 更新时间：2026-07-24

- Recent developments in enzymatic reactive distillation coupling technology
- CIESC Journal Vol. 71, Issue 1, Pages: 122-137(2020)
- 作者机构：
  
  1. 福州大学石油化工学院，福建福州 350116
  2. 天津科技大学化工与材料学院，天津300457
- 作者简介：
- 基金信息：
- DOI：10.11949/0438-1157.20191232
  CLC： Q 814;TQ 028.1⁺3
- Received：23 October 2019，
  
  Revised：2019-10-29，
  
  Online First：12 August 2020，
  
  Published：05 January 2020
- 稿件说明：
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王清莲, 王晓达, 王红星, 黄智贤, 叶长燊, 邱挺. 酶反应精馏耦合技术研究进展[J]. 化工学报, 2020, 71(1): 122-137

WANG Qinglian, WANG Xiaoda, WANG Hongxing, HUANG Zhixian, YE Changshen, QIU Ting. Recent developments in enzymatic reactive distillation coupling technology[J]. CIESC Journal, 2020, 71(1): 122-137
王清莲, 王晓达, 王红星, 黄智贤, 叶长燊, 邱挺. 酶反应精馏耦合技术研究进展[J]. 化工学报, 2020, 71(1): 122-137 DOI： 10.11949/0438-1157.20191232.

WANG Qinglian, WANG Xiaoda, WANG Hongxing, HUANG Zhixian, YE Changshen, QIU Ting. Recent developments in enzymatic reactive distillation coupling technology[J]. CIESC Journal, 2020, 71(1): 122-137 DOI： 10.11949/0438-1157.20191232.

摘要

酶反应精馏是将酶催化反应与精馏过程进行耦合，可有效打破反应化学平衡的限制，提高酶反应转化率和选择性，是一种新型化工过程强化技术。本文分别从酶催化剂及其催化反应机制、酶催化剂装填方式、酶催化反应与精馏耦合型式、酶反应精馏耦合技术的应用案例等方面综述了酶反应精馏耦合技术的研究进展，分析表明：目前酶反应精馏耦合技术的开发尚不成熟，且与化学催化剂催化的反应精馏过程不同，酶反应精馏工艺过程开发还需考虑酶催化反应温度、底物浓度等因素对酶催化活性影响。在后续研究中，可分别从研究体系、酶的固定化技术、酶催化剂装填方式、酶反应精馏理论研究、酶反应精馏耦合工艺开发等方面开展强化研究。

Abstract

Enzymatic reactive distillation which combines the enzyme-catalyzed reaction with distillation process can be used to break the limitation of reaction equilibrium and improve the conversion and selectivity effectively. It is a new process intensification technology. In this paper

the progress of enzymatic reactive distillation coupling technology is reviewed from the enzyme catalyst and its catalytic reaction mechanism

the packing method of enzyme catalyst

the coupling mode of enzyme reaction and distillation process and several application cases. It shows that current development of enzyme reactive distillation coupling technique is not mature. The enzyme-catalyzed reactive distillation is quite different with the reactive distillation catalyzed by chemical catalyst. And the influences of parameters such as reaction temperature

substrate concentration on enzyme catalytic activity should be considered. In the future

the strengthening research can be carried out from the research system

enzyme immobilization technology

enzyme catalyst loading mode

enzyme reactive distillation theory research

enzyme reactive distillation coupling process development and so on.

关键词

Keywords

references

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