Microbial synthesis and transformation of plant-derived natural products

XUE Haijie; WANG Ying; LI Chun

doi:10.11949/0438-1157.20190618

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Microbial synthesis and transformation of plant-derived natural products

Reviews and monographs | 更新时间：2026-07-24

- Microbial synthesis and transformation of plant-derived natural products
- CIESC Journal Vol. 70, Issue 10, Pages: 3825-3835(2019)
- 作者机构：
  
  北京理工大学化学与化工学院生化工程系，北京 100081
- 作者简介：
- 基金信息：
- DOI：10.11949/0438-1157.20190618
  CLC： Q 819
- Received：04 June 2019，
  
  Revised：2019-07-13，
  
  Online First：24 July 2026，
  
  Published：05 October 2019
- 稿件说明：
移动端阅览
薛海洁, 王颖, 李春. 植物天然产物的微生物合成与转化[J]. 化工学报, 2019, 70(10): 3825-3835

XUE Haijie, WANG Ying, LI Chun. Microbial synthesis and transformation of plant-derived natural products[J]. CIESC Journal, 2019, 70(10): 3825-3835
薛海洁, 王颖, 李春. 植物天然产物的微生物合成与转化[J]. 化工学报, 2019, 70(10): 3825-3835 DOI： 10.11949/0438-1157.20190618.

XUE Haijie, WANG Ying, LI Chun. Microbial synthesis and transformation of plant-derived natural products[J]. CIESC Journal, 2019, 70(10): 3825-3835 DOI： 10.11949/0438-1157.20190618.

摘要

植物天然产物是一类结构复杂、性能多样的次级代谢产物，广泛应用于食品、药品、化妆品等多个领域。目前植物天然产物的主要来源依赖于从植物中提取，这种生产方式周期长且占用大量耕地。微生物细胞因其生长周期短、操作简便、环境友好、大规模发酵可控等优势而被广泛研究用以替代传统的植物提取法。目前利用微生物细胞工厂合成和转化植物天然产物已成为研究的热点，实现了萜类、黄酮、生物碱、皂苷等多种植物天然产物的合成和转化。本文分别从从头合成和生物转化的角度综述了微生物细胞工厂在植物天然产物合成中的应用，为更加系统、深入地研究植物天然产物的微生物合成与转化提供参考。

Abstract

Plant-derived natural products are a class of secondary metabolites with complex structures and diverse properties

which are widely used in food

medicine

cosmetics and other fields. At present

the main source of plant-derived natural products is direct extraction from plants

which is time consuming and farming land occupying. Microbial synthesis has been studied to produce plant-derived natural products for the advantages of short growth cycle

mature manipulating methods and controllable large-scale fermentation. Nowadays

it has attracted many attentions to achieve biosynthesis and transformation of plant-derived natural products employing microbial cells. Many kinds of natural products such as terpenoids

flavonoids

alkaloids and saponins have been successfully synthesized in microbes. In this review

the applications of microbial cell factories in the synthesis of plant-derived natural products have been summarized as well as different strategies

which will be helpful for the systematic and in-depth study in the synthesis and transformation of plant-derived natural products.

关键词

Keywords

references

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