Preparation and characterization of biodegradable nanoparticles from methoxy poly(ethylene glycol)- poly (D,L-lactide)block copolymers as novel drug carriers

JIANG Wei; WANG Yundong; ZHANG Jianzheng; GAN Quan; ZHANG Hanwei; BEI Jianzhong; ZHAO Xiuwen; FEI Weiyang

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Preparation and characterization of biodegradable nanoparticles from methoxy poly(ethylene glycol)- poly (D,L-lactide)block copolymers as novel drug carriers

更新时间：2026-03-26

- Preparation and characterization of biodegradable nanoparticles from methoxy poly(ethylene glycol)- poly (D,L-lactide)block copolymers as novel drug carriers
- CIESC Journal Vol. 57, Issue 2, (2006)
- 作者机构：
  
  清华大学化工系化学工程联合国家重点实验室
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Online First：25 February 2006，
  
  Published：2006
- 稿件说明：
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JIANG Wei, WANG Yundong, ZHANG Jianzheng, et al. Preparation and characterization of biodegradable nanoparticles from methoxy poly(ethylene glycol)- poly (D,L-lactide)block copolymers as novel drug carriers[J]. CIESC Journal, 2006, 57(2).
DOI：

JIANG Wei, WANG Yundong, ZHANG Jianzheng, et al. Preparation and characterization of biodegradable nanoparticles from methoxy poly(ethylene glycol)- poly (D,L-lactide)block copolymers as novel drug carriers[J]. CIESC Journal, 2006, 57(2). DOI：

摘要

Abstract

Methoxy poly(ethylene glycol)-poly(D

L-lactide) block copolymers (PEG-PLA) were prepared through ring-opening polymerization.The oil in water suspension method was used to prepare block copolymer micelles. The critical micelle concentration (CMC) by fluorescence spectroscopy was 0.0056 mg8226;ml-1. The physical state of the inner core region of micelles was characterized with 1HNMR. The size of indomethacin (IMC) loaded micelles measured by dynamic light scattering (DLS) showed narrow monodisperse size distribution and the average diameters were less than 50 nm. In addition

the nanoparticles with relatively high drug loading content (DLC) were obtained.

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