Isolation of desacetyl cephalosporin C by activated carbon

YU Haijun; CHEN Ligong; ZHAO Zijian; DONG Rongmei; TAN Qingzhong

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Isolation of desacetyl cephalosporin C by activated carbon

更新时间：2026-03-26

- Isolation of desacetyl cephalosporin C by activated carbon
- CIESC Journal Vol. 57, Issue 2, (2006)
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- Online First：25 February 2006，
  
  Published：2006
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YU Haijun, CHEN Ligong, ZHAO Zijian, et al. Isolation of desacetyl cephalosporin C by activated carbon[J]. CIESC Journal, 2006, 57(2).
DOI：

YU Haijun, CHEN Ligong, ZHAO Zijian, et al. Isolation of desacetyl cephalosporin C by activated carbon[J]. CIESC Journal, 2006, 57(2). DOI：

摘要

利用粉状活性炭为吸附剂，处理头孢菌素C生产过程中的废弃液，实现了去乙酰头孢菌素C(DCPC)和头孢菌素C(CPC)及其他杂质的有效分离.以乙醇-水和异丙醇-水体系作为洗脱剂，得到纯度80%的DCPC溶液.乙醇-水体系收率可达75%，异丙醇-水体系收率可达80%.实验表明，15%乙醇-水和15%异丙醇-水体系分离效果较差;10%乙醇-水和10%异丙醇-水体系洗脱力较弱;12%～13%乙醇-水和12%～13%异丙醇-水体系的洗脱和分离效果较好;13%异丙醇-水体系优于13%乙醇-水体系.

Abstract

The effective separation of desacetyl cephalosporin C(DCPC) from cephalosporin C(CPC) and other impurities was achieved by using the powdery activated carbon as an adsorbent to deal with the waste drainage from the current process for CPC production.By eluting the carbon cake with ethanol-water system or isopropanol-water system

a DCPC solution of 80% purity was obtained. The yield for ethanol-water system was 75%

and that for isopropanol-water system could reach 80%.The experiments showed that separation was not good by eluting the adsorbent with 15% ethanol solution or 15% isopropanol solution

and 10% ethanol solution or 10% isopropanol solution was weak in elution.The good results of elution and separation were obtained by using 12%—13% ethanol solution or 12%—13% isopropanol solution;furthermore

13% isopropanol solution had a better effect than 13% ethanol solution.

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