PRODUCTION OF THROMBOLYTIC ENZYME BY DO-STAT BATCH FERMENTATION EMPLOYING Bacillus subtilis Hl-986

韩润林; 张小勇; 李佐虎; 张建安

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PRODUCTION OF THROMBOLYTIC ENZYME BY DO-STAT BATCH FERMENTATION EMPLOYING Bacillus subtilis Hl-986

更新时间：2025-12-16

- PRODUCTION OF THROMBOLYTIC ENZYME BY DO-STAT BATCH FERMENTATION EMPLOYING Bacillus subtilis Hl-986
- CIESC Journal Issue S1, (2000)
- 作者机构：
  
  中国科学院化工冶金研究所生化工程国家重点实验室!北京 100080,中国科学院化工冶金研究所生化工程国家重点实验室!北京 100080,中国科学院化工冶金研究所生化工程国家重点实验室!北京 100080,清华大学化学工程系!北京100084
- 作者简介：
- 基金信息：
- DOI：
  CLC： Q92
- Online First：30 December 2000，
  
  Published：30 December 2000
- 稿件说明：
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韩润林, 张小勇, 李佐虎, et al. PRODUCTION OF THROMBOLYTIC ENZYME BY DO-STAT BATCH FERMENTATION EMPLOYING Bacillus subtilis Hl-986[J]. CIESC Journal, 2000, (S1).
DOI：

韩润林, 张小勇, 李佐虎, et al. PRODUCTION OF THROMBOLYTIC ENZYME BY DO-STAT BATCH FERMENTATION EMPLOYING Bacillus subtilis Hl-986[J]. CIESC Journal, 2000, (S1). DOI：

摘要

本文以枯草杆菌（Ｂａｃｉｌｌｕｓ　ｓｕｂｔｉｌｉｓ）ＨＬ－９８６为试验菌株，对其恒溶氧发酵生产溶栓酶的的过程进行了研究，并与恒通气速率发酵作了比较。结果表明：与恒通气速率发酵相比，恒溶氧发酵可使溶栓酶生产能力提高３８．８％，在２２ｈ时溶栓酶活力可达９３０ＩＵ／ｍｌ，最佳条件是在发酵初期控制恒溶氧１５％。

Abstract

DO-stat batch fermentation of a thrombolytic enzyme from Bacillus subtilis HL-986 was studied. The thrombolytic enzyme yield reached 930IU/ml by DO-stat fermentation

and was increased 38.8% compared with constant aeration rate. The optimum DO-stat level is 15% controlled in the beginning of fermentstion.

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