CONSTRUCTION OF PARAMETER SET FOR SYSTEMATIC EVALUATION ON ION EXCHANGERS  USED IN BIOSEPARATION

李伟; 欧阳藩

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CONSTRUCTION OF PARAMETER SET FOR SYSTEMATIC EVALUATION ON ION EXCHANGERS USED IN BIOSEPARATION

更新时间：2025-12-16

- CONSTRUCTION OF PARAMETER SET FOR SYSTEMATIC EVALUATION ON ION EXCHANGERS USED IN BIOSEPARATION
- CIESC Journal Issue S1, (2000)
- 作者机构：
  
  中科院化工冶金研究所生化工程国家重点实验室!北京100080,中科院化工冶金研究所生化工程国家重点实验室,北京,100080
- 作者简介：
- 基金信息：
- DOI：
  CLC： Q028
- Online First：30 December 2000，
  
  Published：30 December 2000
- 稿件说明：
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李伟, 欧阳藩. CONSTRUCTION OF PARAMETER SET FOR SYSTEMATIC EVALUATION ON ION EXCHANGERS USED IN BIOSEPARATION[J]. CIESC Journal, 2000, (S1).
DOI：

李伟, 欧阳藩. CONSTRUCTION OF PARAMETER SET FOR SYSTEMATIC EVALUATION ON ION EXCHANGERS USED IN BIOSEPARATION[J]. CIESC Journal, 2000, (S1). DOI：

摘要

填料评估指标体系的构建是填料综合评估的前提。根据生化分离中对填料的要求，本文将离子交换填料的评估指标分成两方面：即稳定性能与操作性能，其中稳定性为达成性指标，操作性为评优指标。后者可以用产率来概括，由３个因素构成，即动态吸附容量、得率和循环时间。得率可通过回收率和分离度来反映，循环时间可通过流速与再生系数反映。上述结构组成离子交换填料评估指标体系。文献统计及实验数据分析证实了指标集构建的合理性。

Abstract

The construction Of evaluation parameter set is the prerequisite of systematic evaluation. According to the requirement in bioseparation process

an evaluation parameter set is put forward which consists of parameters on media stability and chromatographic property. Stability parameters are of yes/no characteristics while chromatographic parameters are comparable and can be summarized by productivity. Productivity can be divided into dynamic binding capacity

yield and cycle time

with yield influenced by recovery

resolution and cycle time by flow rate

regeneration factor.The hierarchical structure forms an evaluation parameter let for ion exchanger systematic evaluation. Its soundness is supported by statistics of references on media characterization.

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