The Delivery Kinetics of Matrix Diffusion-Controlled Polymer/Drug Slab Release System

王绍亭; 袁静华

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The Delivery Kinetics of Matrix Diffusion-Controlled Polymer/Drug Slab Release System

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- The Delivery Kinetics of Matrix Diffusion-Controlled Polymer/Drug Slab Release System
- CIESC Journal Issue 2, (1991)
- 作者机构：
  
  天津大学化工系,天津大学化工系 ,天津,天津
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Online First：25 April 1991，
  
  Published：25 April 1991
- 稿件说明：
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王绍亭, 袁静华. The Delivery Kinetics of Matrix Diffusion-Controlled Polymer/Drug Slab Release System[J]. CIESC Journal, 1991, (2).
DOI：

王绍亭, 袁静华. The Delivery Kinetics of Matrix Diffusion-Controlled Polymer/Drug Slab Release System[J]. CIESC Journal, 1991, (2). DOI：

摘要

本文将化学工程学原理应用于药物控制释放这一交叉学科

针对膜相扩散释放进行了动力学研究

建立、推导了“非稳态、有扩散边界层影响的释放动力学模型’

解决了现有模型“准稳态”假设产生的偏差

使模型更接近于实际释放过程.根据医疗科学和药物控制释放技术的发展趋势

设计了新颖的聚乙烯-乙烯醇/维生素B_(12)混合药膜释放体系.利用该体系验证了本文所建立的模型.

Abstract

The principle of chemical engineering was applied to drug delivery. Am unsteady-state delivery kinetics model with boundary diffusion layer resistance was established to replace the "Pseudosteady-state Assumption" which deviates from the real delivery process. A novel poly (ethylene-vinyl alcohol)/vitamin B12 slab delivery system was designed and used to verify the model. The results showed that the model was effective in describing and predicting the delivery behaviors for a diffusion-controlled polymer/drug release system.

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