Application of Adaptive Estimation in Spiramycin Fermentation Processes

Shi Yuan; Li Yourong; Chen Minheng and Yuan Weikang(East China Institute of Chemical Technology; Shanghai)

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Application of Adaptive Estimation in Spiramycin Fermentation Processes

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- Application of Adaptive Estimation in Spiramycin Fermentation Processes
- CIESC Journal Issue 3, (1989)
- 作者机构：
  
  华东化工学院,华东化工学院,华东化工学院,华东化工学院 ,上海,上海,上海,上海
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Online First：25 June 1989，
  
  Published：25 June 1989
- 稿件说明：
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Shi Yuan, Li Yourong, Chen Minheng and Yuan Weikang(East China Institute of Chemical Technology, et al. Application of Adaptive Estimation in Spiramycin Fermentation Processes[J]. CIESC Journal, 1989, (3).
DOI：

Shi Yuan, Li Yourong, Chen Minheng and Yuan Weikang(East China Institute of Chemical Technology, et al. Application of Adaptive Estimation in Spiramycin Fermentation Processes[J]. CIESC Journal, 1989, (3). DOI：

摘要

以生化反应元素平衡和发酵罐物料守恒为基础

成用自适估计理论消除螺旋霉素发酵控制过程白噪声干扰

估计菌体浓度.从而克服菌体生长动力学以其复杂性、近似性造成实时估计的困难.探讨了总核酸浓度和菌体浓度间的关系

估计值和实验值在发酵周期内平均相对误差符合估计精度.

Abstract

Based on the element balances and bioreactor material conservation of a biochemical reaction

adaptive estimation theory was employed to eliminate white noises during the estimation of cell concentration in spiramycin fermentation processes. The scheme precluded the estimation problems introduced by the complexity and uncertainty of cell growth models. In addition

the relation between the total nucleic acid concentration and the cell concentration was investigated. During spiramycin fermentation

which lasted 100 hours

the estimation values of cell concentration agreed quite well with the experimental results.

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