The experimental phase equilibria data under high pressure for CO2-i-C3H7OH binary system and CO2-i-C3H7OH-H2O ternary system were measured by using the static method. The results indicated that isopropanol could be separated from the aqueous solution and the corresponding azeotrope could be broken by extraction with supercritical carbon dioxide. A thermodynamic model for CO2-i-C3H7OH-H2O ternary system has Leen established by the use of SRK equation and Huran-Vidal mixing rule. The ternary vapor liquid equilibria could be predicted by this model with binary parameters only. The abrupt change of the direction of equilibrium tie lines with temperature and pressure could also be described successfully. Various operation conditions for isopropanol extraction with supercritical carbon dioxide are also discussed.