Synthesis of 2-pyridinamines and their alkyl derivatives from 2-cyanopyridines

戴立言 方俊 王晓钟 陈英奇

您当前的位置：

首页 >

文章列表页 >

Synthesis of 2-pyridinamines and their alkyl derivatives from 2-cyanopyridines

更新时间：2025-12-10

- Synthesis of 2-pyridinamines and their alkyl derivatives from 2-cyanopyridines
- CIESC Journal Issue 3, (2007)
- 作者机构：
  
  浙江大学材化学院制药工程研究所
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Online First：05 March 2007，
  
  Published：05 March 2007
- 稿件说明：
移动端阅览
戴立言方俊王晓钟陈英奇. Synthesis of 2-pyridinamines and their alkyl derivatives from 2-cyanopyridines[J]. CIESC Journal, 2007, (3).
DOI：

戴立言方俊王晓钟陈英奇. Synthesis of 2-pyridinamines and their alkyl derivatives from 2-cyanopyridines[J]. CIESC Journal, 2007, (3). DOI：

摘要

本文研究2-氨基吡啶及其衍生物的合成。目标产物以氰基吡啶为原料，以水和丙酮为混合溶剂，在稀碱溶液中，以过氧化氢为催化剂进行不完全水解，然后用新制的次溴酸钠进行霍夫曼降解反应制得。此合成路线周期简短，原料廉价易得，工艺操作简便，反应条件温和，具有较高的工业应用价值。

Abstract

The preparation of a series of 2-pyridinamines and their alkyl derivatives is described.The target compounds are synthesized starting from corresponding 2-cyanopyridines

via incomplete hydrolysis in the presence of hydrogen peroxide in the dilute alkaline mixture of acetone-2% sodium hydroxide solution

and Hoffmann degradation reaction with freshly made NaBrO.This route is of industrial value because of cheap and readily available materials

moderate reaction conditions and convenient operations.

关键词

Keywords

references

Views

666

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Research on the characterization of the molecular weight and its distribution of perfluoropolyether

Progress of solar photo-thermo-catalysis for ammonia synthesis and decomposition under mild conditions

Effect of belt structure design on the vulcanization characteristics of all-steel radial tires

Advantages and risks of swirling cooling granulation towers

Hydrolysis reaction mechanism of CNCl on the surface of composite metal CuCr2O4

Related Author

No data

Related Institution

No data

⁰