气溶胶溶剂萃取系统技术制备聚乳酸纳米颗粒

YU Wenli; ZHAO Yaping; ZHANG Hejun

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气溶胶溶剂萃取系统技术制备聚乳酸纳米颗粒

更新时间：2025-12-10

- 气溶胶溶剂萃取系统技术制备聚乳酸纳米颗粒
- CIESC Journal Issue 7, (2006)
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- Online First：25 July 2006，
  
  Published：25 July 2006
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YU Wenli, ZHAO Yaping, ZHANG Hejun. 气溶胶溶剂萃取系统技术制备聚乳酸纳米颗粒[J]. CIESC Journal, 2006, (7).
DOI：

YU Wenli, ZHAO Yaping, ZHANG Hejun. 气溶胶溶剂萃取系统技术制备聚乳酸纳米颗粒[J]. CIESC Journal, 2006, (7). DOI：

摘要

采用气溶胶溶剂萃取系统制备聚乳酸（PLA）微细颗粒.用扫描电镜考察了工艺参数温度(35～55℃)、压力(8～20 MPa)、PLA溶液浓度(0.1～0.5 g8226;ml-1)及其流速(140～400 ml8226;h-1)、PLA相对分子质量(Mw：10000～100000)对产品颗粒形貌及粒径的影响;采用X射线衍射谱仪分析了产品的结晶性能.结果表明，当Mw＝100000或PLA溶液浓度达到1 g8226;ml-1时，产品为黏性薄膜，无法得到微球状颗粒产品，当Mw小于100000或PLA溶液浓度小于1 g8226;ml-1时，产品为微球状颗粒，在本研究范围内

温度和压力是影响粒径的主要因素，升高压力、降低温度可显著降低PLA颗粒粒径.在20 MPa，35 ℃，PLA溶液流速为240 ml8226;h-1、浓度0.1 g8226;ml-1、相对分子质量Mw=10000条件下成功制备了粒径介于200～600nm 的PLA微球.XRD分析显示产品晶型几乎没有变化，但结晶度大大减小.

Abstract

Poly lactic acid(PLA) microparticles were prepared by a supercritical fluid method

called the aerosol solvent extraction system method.The effects of pressure

temperature

PLA solution concentration and its flow rates

and PLA molecular weight (Mw) on the morphology and particle size (PS) of the resulting PLA microparticles were investigated.The results showed that a viscous film was found at sinter filter fixed on the bottom of the precipitator when Mw was 100000

or PLA solution concentration was 1 g8226;ml-1

when Mw was less than 100000 or PLA solution concentration was smaller than 1 g8226;ml-1

PLA microparticles were produced.In the scope of study here

pressure and temperature were the most significant factors on PS

and increasing pressure

or decreasing temperature could lead to a significant decrease in PS.At 20 MPa，35℃，PLA flow rate 240 ml8226;h-1，concention 0.1 g8226;ml-1

Mw=10000

the PLA microparticles with a PS of 200～600 nm were successfully obtained.XRD suggested that there was no significant change in crystalline type

but significant decrease in the crystallinity of the resulting PLA products was observed.

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