MATHEMATICAL ANALYSIS FOR SENSITIVITY OF PARAMETERS TO DETERMINE ENANTIOMERIC RATIO IN ENANTIOSELECTIVE BIOCATALYSIS

GONG Pengfei; DAI Lin; WU Huiyuan; XU Jianhe; ZHANG Yuanxing

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MATHEMATICAL ANALYSIS FOR SENSITIVITY OF PARAMETERS TO DETERMINE ENANTIOMERIC RATIO IN ENANTIOSELECTIVE BIOCATALYSIS

更新时间：2025-12-10

- MATHEMATICAL ANALYSIS FOR SENSITIVITY OF PARAMETERS TO DETERMINE ENANTIOMERIC RATIO IN ENANTIOSELECTIVE BIOCATALYSIS
- CIESC Journal Issue 5, (2001)
- 作者机构：
  
  华东理工大学生物反应器工程国家重点实验室
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Online First：25 May 2001，
  
  Published：25 May 2001
- 稿件说明：
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GONG Pengfei, DAI Lin, WU Huiyuan, et al. MATHEMATICAL ANALYSIS FOR SENSITIVITY OF PARAMETERS TO DETERMINE ENANTIOMERIC RATIO IN ENANTIOSELECTIVE BIOCATALYSIS[J]. CIESC Journal, 2001, (5).
DOI：

GONG Pengfei, DAI Lin, WU Huiyuan, et al. MATHEMATICAL ANALYSIS FOR SENSITIVITY OF PARAMETERS TO DETERMINE ENANTIOMERIC RATIO IN ENANTIOSELECTIVE BIOCATALYSIS[J]. CIESC Journal, 2001, (5). DOI：

摘要

Abstract

The enantiomeric ratio ( E ) is frequently used to characterize the enantioselectivity in enzyme-catalyzed kinetic resolution. In this paper two methods are evaluated in terms of accuracy

sensitivity towards E and its distribution.For the equation of Chen et al

the probability of r(eep)∈[0.5

1.0]

the influence on E of enanatiomeric excess of product ( eep)

nearly reaches 0.75.The probability of r(eep)∈[0.7

1.0] exceeds one half.All r(eep) values are higher than 0.6 at conversion ratio ( C ) below 50%. For the equation of Rakels et al

the majority of r(eep) exceeds 0.6 when ee s

enantiomeric excess of substrate is lower and eep is higher.During the final phase of a reaction when ees is large

the changes of ees have greater effects on E than that of eep

but the probabilities for the above two cases do not exceed 0.5.In addition

there are quite a few situations in which r(eep) is equal to 0.4

0.5 and 0.6. This is the most distinguished discrimination of two methods and may also be the primary reason for which the latter is superior to the former.

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