COLUMN DYNAMICS OF TAXOL PURIFICATION ON REVERSED PHASE CHROMATOGRAPHY

ZHANG Zhiqiang; SU Zhiguo; GU Tingyue

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COLUMN DYNAMICS OF TAXOL PURIFICATION ON REVERSED PHASE CHROMATOGRAPHY

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- COLUMN DYNAMICS OF TAXOL PURIFICATION ON REVERSED PHASE CHROMATOGRAPHY
- CIESC Journal Issue 6, (2001)
- 作者机构：
  
  1. 中国科学院化工冶金研究所生化工程国家重点实验室
  2. 中国科学院微生物研究所微生物资源室
  3. 俄亥俄大学化工系
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Online First：25 June 2001，
  
  Published：25 June 2001
- 稿件说明：
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ZHANG Zhiqiang, SU Zhiguo, GU Tingyue. COLUMN DYNAMICS OF TAXOL PURIFICATION ON REVERSED PHASE CHROMATOGRAPHY[J]. CIESC Journal, 2001, (6).
DOI：

ZHANG Zhiqiang, SU Zhiguo, GU Tingyue. COLUMN DYNAMICS OF TAXOL PURIFICATION ON REVERSED PHASE CHROMATOGRAPHY[J]. CIESC Journal, 2001, (6). DOI：

摘要

通过考察物质在液固两相之间的基本传递现象

建立了常压非线性柱层析过程的速率模型 .对紫杉醇在C18-硅胶柱上分离纯化过程进行了数学分析 .模型计算值与实验值吻合良好 .研究物料浓度、进料速度、层析柱大小等因素对紫杉醇层析过程的影响说明

建立的柱动力学模型能指导紫杉醇层析过程简捷而有效地放大

Abstract

Taxol

originally isolated from the bark of Taxus brevifolia

is a very important new anti-tumor drug.Reversed phase chromatography provides a rapid

efficient

and inexpensive method to separate and purify taxol. However

it is very important to scae-up the isolation process in order to obtain a large amount of taxol. From studies on the basic transport phenomena between solid phase and liquid phase

the rate model for non linear liquid chromatography under normal pressure is proposed.The process of taxol separation on C 18 - silica gel column could be described by this model very well.The numerical solution of model agrees well with experimental data.The factors affecting the separation of taxol

including feed concentration

feed rate and column size are investigated.It is confirmed that the mathematical model could be very useful for scaling-up chromatographic operation.

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