INQUIRY INTO MECHANISM OF FDP ACCUMULATING   USING MODEL OF METABOLIC PATHWAY FLUX

应汉杰; 欧阳平凯

您当前的位置：

首页 >

文章列表页 >

INQUIRY INTO MECHANISM OF FDP ACCUMULATING USING MODEL OF METABOLIC PATHWAY FLUX

更新时间：2025-12-16

- INQUIRY INTO MECHANISM OF FDP ACCUMULATING USING MODEL OF METABOLIC PATHWAY FLUX
- CIESC Journal Issue 3, (2000)
- 作者机构：
  
  南京化工大学生物工程与科学系!南京210009,南京化工大学生物工程与科学系,南京,210009
- 作者简介：
- 基金信息：
- DOI：
  CLC： 629
- Online First：25 June 2000，
  
  Published：25 June 2000
- 稿件说明：
移动端阅览
应汉杰, 欧阳平凯. INQUIRY INTO MECHANISM OF FDP ACCUMULATING USING MODEL OF METABOLIC PATHWAY FLUX[J]. CIESC Journal, 2000, (3).
DOI：

应汉杰, 欧阳平凯. INQUIRY INTO MECHANISM OF FDP ACCUMULATING USING MODEL OF METABOLIC PATHWAY FLUX[J]. CIESC Journal, 2000, (3). DOI：

摘要

首次建立了 1

6-二磷酸果糖 (FDP)累积的代谢途径流量模型 .应用该模型求解FDP累积过程中不同时期的代谢流量分配

详细分析了各时期代谢流量分配发生改变的原因

并探讨FDP累积的机理 .细胞膜通透性的改变是FDP积累于胞外的前提条件 ;而代谢网络中HK、PFK、Ald和PK等酶活的调节使主要结点处代谢流量分配发生重大改变

则是FDP在胞外大量积累的关键 .

Abstract

In this paper the model of metabolic pathway flux of FDP accumulation is established and the metabolic flux distributions are obtained at different times of FDP accumulation process.The experiments have showed that FDP accumulation in the medium produced by the present method is due to the redirected flux distributions in this metabolic pathway.The yield of FDP to glucose was only 16.1%.Meanwhile

the results also showed that such metabolic flux alterations at key branch points are often directly opposed by mechanisms for controlling enzyme activity

such as HK

PFK

et al

which have evolved to maintain flux distributions that are optimal for growth.So

in order to overproduce FDP with yeasts

enzyme amplification or other modifications of the product pathway must be done to alter the metabolic flux distributions at the key branch points.

关键词

Keywords

references

Views

339

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Construction of transition metal-based nitrogen-doped carbon and their desulfurization performance

Study on impact of impurities in coal chemical waste salt on solvation of NaCl and Na2SO4

Study on dissolution kinetics of erythromycin thiocyanate

Zn-doped PdO/ZrO2 with rich oxygen vacancies for the synthesis of diphenyl carbonate from CO2 and phenol

Thermo-oxidative degradation characteristics of TPT backsheet from end-of-life photovoltaic modules

Related Author

No data

Related Institution

No data

⁰