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天津大学化工系!天津300072,天津大学化工系!天津300072,天津大学化工系!天津300072,华北制药厂!石家庄050011,华北制药厂,石家庄,050011
Online First:25 February 1996,
Published:25 February 1996
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Wang Jingkang, Zhang Mening, Wan Tao, et al. THE CRYSTALLIZATION PROCESS FOR PENICILLIN G SALT[J]. CIESC Journal, 1996, (1).
DOI:
Wang Jingkang, Zhang Mening, Wan Tao, et al. THE CRYSTALLIZATION PROCESS FOR PENICILLIN G SALT[J]. CIESC Journal, 1996, (1). DOI:
本文研究了β-内酰胺类抗菌素药物真空闪蒸结晶过程.以苄青霉素钾盐为例,测定了该物系的结晶热力学相图与介稳区曲线,应用间歇动态法确定了该物系的结晶动力学参数,进而求取了最佳操作时间表.
In this paper
the vacuum evaporative crystallization process of β lactam antimicrobial pharmaceuticals is studied.The crystallization thermodynamic data
such as the phase equilibrium diagram and the metastable zone of pencillin G potassium are determined.Furthermore
the crystallization kinetic parameters for penicillin G potassium salt in n-butanolwater solution are measured by using an unsteady method.Therefore
the optimal operating time table for the crystallization process is established.
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