ENHANCEMENT OF PENICILLIN G HYDROLYSIS TO 6 - AMINOPENICILLANIC ACID BY IN SITU ION EXCHANGE

陈坚

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ENHANCEMENT OF PENICILLIN G HYDROLYSIS TO 6 - AMINOPENICILLANIC ACID BY IN SITU ION EXCHANGE

更新时间：2025-12-16

- ENHANCEMENT OF PENICILLIN G HYDROLYSIS TO 6 - AMINOPENICILLANIC ACID BY IN SITU ION EXCHANGE
- CIESC Journal Issue 6, (1995)
- 作者机构：
  
  无锡轻工大学生物工程系,无锡,214036
- 作者简介：
- 基金信息：
- DOI：
  CLC： Q464
- Online First：25 December 1995，
  
  Published：25 December 1995
- 稿件说明：
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陈坚. ENHANCEMENT OF PENICILLIN G HYDROLYSIS TO 6 - AMINOPENICILLANIC ACID BY IN SITU ION EXCHANGE[J]. CIESC Journal, 1995, (6).
DOI：

陈坚. ENHANCEMENT OF PENICILLIN G HYDROLYSIS TO 6 - AMINOPENICILLANIC ACID BY IN SITU ION EXCHANGE[J]. CIESC Journal, 1995, (6). DOI：

摘要

采用固定化青霉素酰化酶反应器进行青霉素G水解生产6-氨基青霉烷酸

同时与离子交换柱相组合以连续地去除苯乙酸而维持反应混合液中的低苯乙酸浓度.研究发现

采用随程离子交换法可提高青霉素G水解速率10.2%

同时可从反应混合液中去除53%的苯乙酸;通过确定苯乙酸、青霉素G在离子交换柱中的动力学行为和固定化酶的动力学参数

利用已建立的数学模型

可很好地对青霉素G水解生产6-氨基青霉烷酸过程进行计算机模拟.

Abstract

A combined system of immobilized enzyme reactor and ion exchange column was employed for hydrolysis of Penicillin G to 6 -Aminopenicillanic acid with continuous removal of Phenylacetic acid . In the composite system

the time required for 95% Penicillin G conversion to 6 -Aminopenicillanic acid could be reduced by 10. 8% and 53% of Phenylacetic acid could be removed from the reaction mixture. Based on Phenylacetic acid and Penicillin G dynamics in ion exchange process and immobilized enzyme kinetics

the hydrolysis of Penicillin G was simulated well by computer from the mathematical model developed.

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