THYMOSIN α<sub>１</sub> SYNTHESIS WITH DIC AND ITS IDENTIFICATION

GAN Yiru; HUANG Yongdong; LIU Jinsheng; ZHANG Xuezhu; ZHANG Guifeng

您当前的位置：

首页 >

文章列表页 >

THYMOSIN α_１ SYNTHESIS WITH DIC AND ITS IDENTIFICATION

更新时间：2025-12-10

- THYMOSIN α_１ SYNTHESIS WITH DIC AND ITS IDENTIFICATION
- CIESC Journal Issue 2, Pages: 305-308(2004)
- 作者机构：
  
  1. 天津大学化工学院,天津,300072
  2. 中国科学院过程工程研究所生化工程国家重点实验室,北京,100080
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Online First：25 February 2004，
  
  Published：25 February 2004
- 稿件说明：
移动端阅览
GAN Yiru, HUANG Yongdong, LIU Jinsheng, et al. THYMOSIN α_１ SYNTHESIS WITH DIC AND ITS IDENTIFICATION[J]. CIESC Journal, 2004, (2): 305-308.
DOI：

GAN Yiru, HUANG Yongdong, LIU Jinsheng, et al. THYMOSIN α_１ SYNTHESIS WITH DIC AND ITS IDENTIFICATION[J]. CIESC Journal, 2004, (2): 305-308. DOI：

摘要

Abstract

Thymosin α1 was synthesized manually. The washing condition and the test of the degree of coupling were studied. In addition

the analytical method of crude product was set up. Thymosin α1 was synthesized with the solid-phase method

by using the base-liable Fmoc group to protect the α-amino acid and N

N′-diisopropylcarbodiimide (DIC) as the coupling regent. The crude product was analyzed by reversed-phase high performance liquid chromatography

SDS-PAGE and liquid chromatography/mass spectroscopy.The synthesis yield was 84.89%. The analytical results indicated that the crude product contained much thymosin α1

and the purity was 50.3%. DIC solid-phase chemical synthesis of thymosin α1 was applicable

and the yield was improved greatly compared to other known methods.

关键词

Keywords

references

Views

648

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

APPLICATION OF LIQUID CHROMATOGRAPHY FOR ISOLATION AND PURIFICATION OF SOLID-PHASE SYNTHETIC THYMOSIN α1

Thermal analysis of phase change suspension jet impinging on wall surface covered with variable-shape porous layer

Prediction of biomass pyrolysis product yield based on machine learning algorithms

Performance study of gas-liquid vortex separators under low cross-sectional gas velocity

A hybrid modeling and optimization strategy for sequential simulated moving bed

Related Author

WU Lei

Related Institution

No data

⁰

THYMOSIN α１ SYNTHESIS WITH DIC AND ITS IDENTIFICATION

DOI：

摘要

Abstract

关键词

Keywords

references

THYMOSIN α_１ SYNTHESIS WITH DIC AND ITS IDENTIFICATION