EFFECT OF AGITATION AND MIXING ON HYALURONIC ACID PRODUCTION BY Streptococcus zooepidemicus

GAO Haijun; CHEN Jian; DU Guocheng; ZHANG Yanfang; CHEN Jinchun; CHEN Guoqiang

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EFFECT OF AGITATION AND MIXING ON HYALURONIC ACID PRODUCTION BY Streptococcus zooepidemicus

更新时间：2025-12-10

- EFFECT OF AGITATION AND MIXING ON HYALURONIC ACID PRODUCTION BY Streptococcus zooepidemicus
- CIESC Journal Issue 3, Pages: 350-356(2003)
- 作者机构：
  
  1. 清华大学生物系
  2. 江南大学生物工程学院
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Online First：25 March 2003，
  
  Published：25 March 2003
- 稿件说明：
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GAO Haijun, CHEN Jian, DU Guocheng, et al. EFFECT OF AGITATION AND MIXING ON HYALURONIC ACID PRODUCTION BY Streptococcus zooepidemicus[J]. CIESC Journal, 2003, (3): 350-356.
DOI：

GAO Haijun, CHEN Jian, DU Guocheng, et al. EFFECT OF AGITATION AND MIXING ON HYALURONIC ACID PRODUCTION BY Streptococcus zooepidemicus[J]. CIESC Journal, 2003, (3): 350-356. DOI：

摘要

研究了透明质酸的流变学特性以及搅拌和混合对兽疫链球菌发酵生产透明质酸的影响。结果表明：透明质酸溶液属于典型的非牛顿凯松流体；搅拌转速和透明质酸浓度对气液传氧速率有很大影响；在较高的搅拌速率下发酵时可以得到较高的透明质酸产量，650 r·min-1时透明质酸产量为4.1 g·L-1，产率系数为0.08 g·g-1；用有效搅拌模型分析发酵过程发现，只有在高搅拌转速时发酵体系才处于全部混合状态。

Abstract

Rheological features of hyaluronic acid and effects of agitation and mixing on hyaluronic acid (HA) production by Streptococcus zooepidemicus were investigated. HA solution is a non-Newtonian Casson-fluid. Oxygen transfer rate between gas and liquid phase was influenced by agitation and concentration of HA. High HA production was accompanied by faster agitation. HA concentration and yield of HA at 650 r·min-1 reached 4.1 g·L-1

0.08 g·g-1 respectively. Based on circular cylinder cavern model

culture system was in perfect mixing state only at high speed agitation.

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